Dhx30 DExH-box helicase 30 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhx30provided by RGD
Official Full Name: DExH-box helicase 30provided by RGD
Primary source: RGD:1308888
See related: EnsemblRapid:ENSRNOG00000029194 AllianceGenome:RGD:1308888
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA binding activity; chromatin binding activity; and helicase activity. Predicted to be involved in central nervous system development and mitochondrial large ribosomal subunit assembly. Predicted to be located in cytosol; mitochondrial nucleoid; and ribonucleoprotein granule. Predicted to be active in cytoplasm and nucleus. Orthologous to human DHX30 (DExH-box helicase 30). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 115.5), Thymus (RPKM 110.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118943186..118975319, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (110064751..110096954, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (118160315..118194674, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU015424 (e-PCR)
- UniSTS:208457

BF393382 (e-PCR)
- UniSTS:244076

Dhx30 (e-PCR), detects polymorphism
- UniSTS:479097

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables G-quadruplex RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial large ribosomal subunit assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial large ribosomal subunit assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial large ribosomal subunit assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrial nucleoid	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in ribonucleoprotein granule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX30

Names: DEAH (Asp-Glu-Ala-His) box helicase 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; DEAH-box helicase 30; putative ATP-dependent RNA helicase DHX30

NP_001013267.1

EC 3.6.4.13

XP_006243888.1

EC 3.6.4.13

XP_006243891.1

EC 3.6.4.13

XP_006243893.1

EC 3.6.4.13

XP_017451288.1

EC 3.6.4.13

XP_017451289.1

EC 3.6.4.13

XP_063122008.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013249.1 → NP_001013267.1 ATP-dependent RNA helicase DHX30

See identical proteins and their annotated locations for NP_001013267.1

Status: PROVISIONAL

Source sequence(s)

BC091359

UniProtKB/Swiss-Prot

Q5BJS0

UniProtKB/TrEMBL

A0A8I5YC14

Conserved Domains (5) summary

smart00490
Location:686 → 785

HELICc; helicase superfamily c-terminal domain

smart00487
Location:438 → 617

DEXDc; DEAD-like helicases superfamily

smart00847
Location:857 → 940

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:452 → 593

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:980 → 1102

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118943186..118975319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243831.4 → XP_006243893.1 ATP-dependent RNA helicase DHX30 isoform X5

UniProtKB/TrEMBL

A0A8I6ARW5

Related

ENSRNOP00000089933.2, ENSRNOT00000109037.2

Conserved Domains (5) summary

smart00490
Location:649 → 748

HELICc; helicase superfamily c-terminal domain

smart00487
Location:401 → 580

DEXDc; DEAD-like helicases superfamily

smart00847
Location:820 → 903

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:415 → 556

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:943 → 1065

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_017595799.3 → XP_017451288.1 ATP-dependent RNA helicase DHX30 isoform X2

UniProtKB/Swiss-Prot

Q5BJS0

UniProtKB/TrEMBL

A0A8I5YC14

Conserved Domains (5) summary

smart00490
Location:686 → 785

HELICc; helicase superfamily c-terminal domain

smart00487
Location:438 → 617

DEXDc; DEAD-like helicases superfamily

smart00847
Location:857 → 940

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:452 → 593

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:980 → 1102

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_017595800.3 → XP_017451289.1 ATP-dependent RNA helicase DHX30 isoform X2

UniProtKB/Swiss-Prot

Q5BJS0

UniProtKB/TrEMBL

A0A8I5YC14

Conserved Domains (5) summary

smart00490
Location:686 → 785

HELICc; helicase superfamily c-terminal domain

smart00487
Location:438 → 617

DEXDc; DEAD-like helicases superfamily

smart00847
Location:857 → 940

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:452 → 593

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:980 → 1102

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_063265938.1 → XP_063122008.1 ATP-dependent RNA helicase DHX30 isoform X3

UniProtKB/TrEMBL

A0A8I5YC14, A0A8I6GHS9

Related

ENSRNOP00000069744.3, ENSRNOT00000084838.3
XM_006243829.5 → XP_006243891.1 ATP-dependent RNA helicase DHX30 isoform X4

UniProtKB/TrEMBL

A0A8I5YC14

Conserved Domains (5) summary

smart00490
Location:677 → 776

HELICc; helicase superfamily c-terminal domain

smart00487
Location:429 → 608

DEXDc; DEAD-like helicases superfamily

smart00847
Location:848 → 931

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:443 → 584

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:971 → 1093

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
XM_006243826.5 → XP_006243888.1 ATP-dependent RNA helicase DHX30 isoform X1

See identical proteins and their annotated locations for XP_006243888.1

UniProtKB/TrEMBL

A0A8I5YC14, A0A8L2QL99, A6I3D1

Related

ENSRNOP00000043896.5, ENSRNOT00000048764.7

Conserved Domains (5) summary

smart00490
Location:714 → 813

HELICc; helicase superfamily c-terminal domain

smart00487
Location:466 → 645

DEXDc; DEAD-like helicases superfamily

smart00847
Location:885 → 968

HA2; Helicase associated domain (HA2) Add an annotation

cd00046
Location:480 → 621

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam07717
Location:1008 → 1130

OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold