Trim32 tripartite motif-containing 32 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trim32provided by RGD
Official Full Name: tripartite motif-containing 32provided by RGD
Primary source: RGD:1305238
See related: EnsemblRapid:ENSRNOG00000010303 AllianceGenome:RGD:1305238
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; transcription coactivator activity; and ubiquitin binding activity. Predicted to be involved in several processes, including defense response to symbiont; regulation of organelle assembly; and regulation of signal transduction. Predicted to act upstream of or within several processes, including muscle cell cellular homeostasis; positive regulation of chemokine (C-C motif) ligand 20 production; and protein ubiquitination. Predicted to be located in nucleus and striated muscle myosin thick filament. Predicted to be active in autophagosome and centrosome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 11; autosomal recessive limb-girdle muscular dystrophy type 2H; and muscular dystrophy. Orthologous to human TRIM32 (tripartite motif containing 32). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 92.6), Adrenal (RPKM 59.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (84020604..84031483)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (79005139..79016615)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (81431554..81449023)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL.
Title: Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL.
TRIM32 promotes inflammatory factor-induced apoptosis of nucleus pulposus cells, in part by degradation of AXIN1 to trigger Beta-catenin signaling.
Title: TRIM32 triggers β-catenin signaling through ubiquitylation of AXIN1 to promote inflammatory factor-induced apoptosis of rat nucleus pulposus cells.
Knockdown of TRIM32 protects hippocampal neurons from oxygen-glucose deprivation-induced oxidative injury through activation of the Nrf2 signaling pathway.
Title: Knockdown of TRIM32 Protects Hippocampal Neurons from Oxygen-Glucose Deprivation-Induced Injury.
suppression of Trim32 promotes the recovery of neurological function after traumatic brain injury.
Title: Suppression of Trim32 Enhances Motor Function Repair after Traumatic Brain Injury Associated with Antiapoptosis.
After sciatic nerve crush, TRIM32 expression is rapidly increased along with neurite outgrowth.
Title: Upregulated Expression of TRIM32 Is Involved in Schwann Cell Differentiation, Migration and Neurite Outgrowth After Sciatic Nerve Crush.
TRIM32 could be a novel therapeutic target for the prevention of cardiac hypertrophy and heart failure
Title: Tripartite motif 32 prevents pathological cardiac hypertrophy.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF387417 (e-PCR)
- UniSTS:260939

UniSTS:234940 (e-PCR)
- UniSTS:234940

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables myosin binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon development	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in free ubiquitin chain polymerization	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine (C-C motif) ligand 20 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in response to UV	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	ISO Inferred from Sequence Orthology more info
involved_in response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in suppression of viral release by host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in autophagosome	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in striated muscle myosin thick filament	ISO Inferred from Sequence Orthology more info
located_in striated muscle myosin thick filament	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase TRIM32

Names: tripartite motif protein 32

NP_001012103.1

EC 2.3.2.27

XP_006238332.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012103.1 → NP_001012103.1 E3 ubiquitin-protein ligase TRIM32

See identical proteins and their annotated locations for NP_001012103.1

Status: PROVISIONAL

Source sequence(s)

BC081980

UniProtKB/TrEMBL

A0A8I5ZWV9, A6J801, F7F4N6, Q66H79

Related

ENSRNOP00000109707.1, ENSRNOT00000121981.1

Conserved Domains (3) summary

cd14961
Location:364 → 646

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:20 → 66

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:99 → 139

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

84020604..84031483

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238270.5 → XP_006238332.1 E3 ubiquitin-protein ligase TRIM32 isoform X1

See identical proteins and their annotated locations for XP_006238332.1

UniProtKB/TrEMBL

A0A8I5ZWV9, A6J801, F7F4N6, Q66H79

Conserved Domains (3) summary

cd14961
Location:364 → 646

NHL_TRIM32_like; NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins

cd16587
Location:20 → 66

RING-HC_TRIM32_C-VII; RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins

cd19806
Location:99 → 139

Bbox1_TRIM32_C-VII; B-box-type 1 zinc finger found in tripartite motif-containing protein 32 (TRIM32) and similar proteins