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    CG5966 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31532, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5966provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029831
    Locus tag
    Dmel_CG5966
    See related
    AllianceGenome:FB:FBgn0029831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141233_at; Dmel\CG5966
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Is expressed in several structures, including adult head; embryonic dorsal epidermis; embryonic head epidermis; embryonic head sensory system; and gut section. Orthologous to several human genes including PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)) and PNLIPRP3 (pancreatic lipase related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5966 in Genome Data Viewer
    Location:
    5D1-5D1; 1-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5988791..5992640)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5882824..5886673)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene female sterile (1) M3 Neighboring gene Glutamate receptor interacting protein Neighboring gene long non-coding RNA:CR44498 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. Williams MJ, et al. PLoS Genet, 2016 Jun. PMID 27280443, Free PMC Article
    2. Nazo, the Drosophila homolog of the NBIA-mutated protein-c19orf12, is required for triglyceride homeostasis. Sreejith P, et al. PLoS Genet, 2024 Feb. PMID 38335241, Free PMC Article
    3. Overexpression of dilp2 causes nutrient-dependent semi-lethality in Drosophila. Sato-Miyata Y, et al. Front Physiol, 2014. PMID 24795642, Free PMC Article
    4. Identification of a novel role for Drosophila MESR4 in lipid metabolism. Tsuda-Sakurai K, et al. Genes Cells, 2015 Apr. PMID 25639854
    5. A critical role of SNF1A/dAMPKalpha (Drosophila AMP-activated protein kinase alpha) in muscle on longevity and stress resistance in Drosophila melanogaster. Tohyama D, et al. Biochem Biophys Res Commun, 2010 Mar 26. PMID 20184862

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5966-PA
    CG5966-PB
    triglyceride lipase
    NP_001284922.1
    NP_572286.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5988791..5992640
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297993.1 → NP_001284922.1  uncharacterized protein Dmel_CG5966, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284922.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDV7
      Conserved Domains (1) summary
      cd00707
      Location:2 → 286
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

    2. NM_132058.3 → NP_572286.1  uncharacterized protein Dmel_CG5966, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572286.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W448
      Related
      FBpp0070831
      Conserved Domains (2) summary
      cd00707
      Location:76 → 390
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:46 → 394
      Lipase; Lipase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W448 Q9W448
    X2JDV7 X2JDV7

    Gene LinkOut

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