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    tok tolkin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42944, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tokprovided by FlyBase
    Official Full Name
    tolkinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004885
    Locus tag
    Dmel_CG6863
    See related
    AllianceGenome:FB:FBgn0004885
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6863; CT21251; Dmel\CG6863; tldr-1; tldr1; tlr; Tlr; TLR; tlr-1; Tlr-1; tlr1; Tok; TOK
    Summary
    Enables metalloendopeptidase activity. Involved in several processes, including axon development; imaginal disc-derived wing vein morphogenesis; and positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in extracellular space. Is expressed in several structures, including amnioproctodeal invagination; epithelium; gut section; imaginal disc; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in atrial heart septal defect 6; congenital heart disease; coronary artery disease; and osteogenesis imperfecta type 13. Orthologous to human BMP1 (bone morphogenetic protein 1); TLL1 (tolloid like 1); and TLL2 (tolloid like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tok in Genome Data Viewer
    Location:
    96A18-96A19; 3-85 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24719697..24749125)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20545419..20574847)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit L Neighboring gene tolloid Neighboring gene abnormal spindle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development. Finelli AL, et al. Genetics, 1995 Sep. PMID 8536976, Free PMC Article
    2. Mutational analysis of the Drosophila tolloid gene, a human BMP-1 homolog. Finelli AL, et al. Development, 1994 Apr. PMID 7600963
    3. Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo. Kellermeyer R, et al. Development, 2020 Oct 29. PMID 32994163, Free PMC Article
    4. Characterization of tolloid-related-1: a BMP-1-like product that is required during larval and pupal stages of Drosophila development. Nguyen T, et al. Dev Biol, 1994 Dec. PMID 7813777
    5. Separable cis-acting control elements for expression of the white gene of Drosophila. Levis R, et al. EMBO J, 1985 Dec 16. PMID 3004962, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.
      Title: Proteolytic cleavage of Slit by the Tolkin protease converts an axon repulsion cue to an axon growth cue in vivo.
    2. Study suggests that by activating Daw and perhaps other TGF-beta ligands, tolloid related provides a permissive signal for axon guidance
      Title: The metalloprotease tolloid-related and its TGF-beta-like substrate Dawdle regulate Drosophila motoneuron axon guidance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defasciculation of motor neuron axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in imaginal disc-derived wing vein morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of activin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tolkin
    Names
    CG6863-PA
    CG6863-PB
    CG6863-PC
    Tolloid-related
    piranha
    tld-related-1
    tok-PA
    tok-PB
    tok-PC
    tolloid-related 1
    NP_001287510.1
    NP_476879.1
    NP_733035.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24719697..24749125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170168.2 → NP_733035.1  tolkin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733035.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23995, Q24132, Q95RA3, Q9VC47
      Related
      FBpp0084068
      Conserved Domains (6) summary
      cd00041
      Location:1271 → 1390
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd04281
      Location:520 → 721
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:840 → 951
      CUB; CUB domain
      pfam01400
      Location:527 → 721
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:1118 → 1153
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00049
      Location:723 → 836
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    2. NM_057531.4 → NP_476879.1  tolkin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476879.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23995, Q24132, Q95RA3, Q9VC47
      Related
      FBpp0084069
      Conserved Domains (6) summary
      cd00041
      Location:1271 → 1390
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd04281
      Location:520 → 721
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:840 → 951
      CUB; CUB domain
      pfam01400
      Location:527 → 721
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:1118 → 1153
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00049
      Location:723 → 836
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    3. NM_001300581.1 → NP_001287510.1  tolkin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287510.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23995, Q24132, Q95RA3, Q9VC47
      Conserved Domains (6) summary
      cd00041
      Location:1271 → 1390
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd04281
      Location:520 → 721
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:840 → 951
      CUB; CUB domain
      pfam01400
      Location:527 → 721
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:1118 → 1153
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00049
      Location:723 → 836
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q49II0 Q49II0
    Q49II5 Q49II5
    Q49II7 Q49II7
    Q49II8 Q49II8
    Q49IJ0 Q49IJ0
    Q49IJ1 Q49IJ1
    Q49IK4 Q49IK4
    Q9VC47.1 Q9VC47

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