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    GMF Glia maturation factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34963, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GMFprovided by FlyBase
    Official Full Name
    Glia maturation factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028894
    Locus tag
    Dmel_CG5869
    See related
    AllianceGenome:FB:FBgn0028894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD03793; BG:DS02740.9; CG5869; dGMF; Dmel\CG5869; DS02740.9; gmf
    Summary
    Predicted to enable Arp2/3 complex binding activity. Involved in several processes, including actin filament debranching; border follicle cell migration; and regulation of actin filament organization. Located in several cellular components, including lamellipodium; nucleus; and perinuclear region of cytoplasm. Is expressed in border follicle cell; centripetal follicle cell; and polar follicle cell. Orthologous to human GMFB (glia maturation factor beta) and GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GMF in Genome Data Viewer
    Location:
    35F1-35F1; 2-52 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16301656..16302954, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16301656..16302954, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44899 Neighboring gene Cytochrome P450 303a1 Neighboring gene heixuedian Neighboring gene uncharacterized protein Neighboring gene crossover suppressor on 2 of Manheim Neighboring gene uncharacterized protein Neighboring gene Syntaxin 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GMF promotes leading-edge dynamics and collective cell migration in vivo. Poukkula M, et al. Curr Biol, 2014 Nov 3. PMID 25308079, Free PMC Article
    2. A tissue specific cytochrome P450 required for the structure and function of Drosophila sensory organs. Willingham AT, et al. Mech Dev, 2004 Oct. PMID 15327788
    3. Genome annotation assessment in Drosophila melanogaster. Reese MG, et al. Genome Res, 2000 Apr. PMID 10779488, Free PMC Article
    4. The actin polymerization factor Diaphanous and the actin severing protein Flightless I collaborate to regulate sarcomere size. Deng S, et al. Dev Biol, 2021 Jan 1. PMID 32980309, Free PMC Article
    5. Dendritic Cytoskeletal Architecture Is Modulated by Combinatorial Transcriptional Regulation in Drosophila melanogaster. Das R, et al. Genetics, 2017 Dec. PMID 29025914, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament debranching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell projection organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glia maturation factor
    Names
    CG5869-PA
    GMF-PA
    glia-maturation factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16301656..16302954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135943.3 → NP_609787.2  glia maturation factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609787.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSR7, Q9NK59, Q9VJL6
      Related
      FBpp0080408
      Conserved Domains (1) summary
      cd11283
      Location:8 → 129
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJL6.2 Q9VJL6

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