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    CG33158 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39834, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG33158provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053158
    Locus tag
    Dmel_CG33158
    See related
    AllianceGenome:FB:FBgn0053158
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10162; CG4638; Dmel\CG33158
    Summary
    Predicted to enable GTPase activity and ribosome binding activity. Predicted to be involved in cytosolic ribosome assembly. Located in cytosol. Is expressed in several structures, including adult brain cell body rind; central brain primordium; embryonic ventral epidermis; embryonic/larval midgut primordium; and epithelium. Human ortholog(s) of this gene implicated in Shwachman-Diamond syndrome. Orthologous to human EFL1 (elongation factor like GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG33158 in Genome Data Viewer
    Location:
    72F1-73A3; 3-44 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16419597..16496560)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16412697..16489660)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Serine incorporator Neighboring gene Glutamyl-tRNA synthetase, mitochondrial Neighboring gene Tyrosyl-tRNA synthetase Neighboring gene doublesex cognate 73A Neighboring gene argos Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene scarlet Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of the Drosophila secreted cuticle protein 73 (dsc73) requires Shavenbaby. Andrew DJ, et al. Dev Dyn, 2008 Apr. PMID 18351665, Free PMC Article
    2. The genetic architecture of larval aggregation behavior in Drosophila. McKinney RM, et al. J Neurogenet, 2021 Sep. PMID 33629904
    3. Functional neurogenomics of the courtship song of male Drosophila melanogaster. Moran CN, et al. Cortex, 2009 Jan. PMID 19054505
    4. Genetics of alcohol consumption in Drosophila melanogaster. Fochler S, et al. Genes Brain Behav, 2017 Sep. PMID 28627812, Free PMC Article
    5. Selection for long and short sleep duration in Drosophila melanogaster reveals the complex genetic network underlying natural variation in sleep. Harbison ST, et al. PLoS Genet, 2017 Dec. PMID 29240764, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 16443902-16446186 mobile_element_type = transposon:Doc{}1012

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytosolic ribosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG33158-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16419597..16496560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176337.2 → NP_788515.1  uncharacterized protein Dmel_CG33158 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH3, Q9VV61
      Related
      FBpp0075148
      Conserved Domains (6) summary
      cd01885
      Location:20 → 249
      EF2; Elongation Factor 2 (EF2) in archaea and eukarya
      cd01681
      Location:658 → 899
      aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
      cd04096
      Location:896 → 974
      eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
      PTZ00416
      Location:15 → 1016
      PTZ00416; elongation factor 2; Provisional
      cd16268
      Location:485 → 572
      EF2_II; Domain II of Elongation Factor 2
      cd16261
      Location:587 → 658
      EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TH3 Q95TH3
    Q9VV61 Q9VV61

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