U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    REPTOR Repressed by TOR [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42930, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    REPTORprovided by FlyBase
    Official Full Name
    Repressed by TORprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039209
    Locus tag
    Dmel_CG13624
    See related
    AllianceGenome:FB:FBgn0039209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0153538.65; CG13624; DM23; DM24; Dmel\CG13624; reptor; Reptor
    Summary
    Enables protein heterodimerization activity. Involved in TORC1 signaling; positive regulation of DNA-templated transcription; and response to starvation. Located in cytosol and nucleus. Is expressed in several structures, including antennal anlage; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and ventral nerve cord. Orthologous to human CREBRF (CREB3 regulatory factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See REPTOR in Genome Data Viewer
    Location:
    96A7-96A9; 3-85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24557368..24582864, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20383090..20408586, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene small nuclear RNA U6 at 96A b Neighboring gene small nuclear RNA U6 at 96A c Neighboring gene long non-coding RNA:CR46094 Neighboring gene uncharacterized protein Neighboring gene molting defective Neighboring gene long non-coding RNA:CR46095

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Protein visualization and manipulation in Drosophila through the use of epitope tags recognized by nanobodies. Xu J, et al. Elife, 2022 Jan 25. PMID 35076390, Free PMC Article
    2. The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. Agrawal N, et al. Cell Metab, 2016 Apr 12. PMID 27076079
    3. The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation. Bjedov I, et al. Genes (Basel), 2020 Sep 3. PMID 32899412, Free PMC Article
    4. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
    5. REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. Tiebe M, et al. Dev Cell, 2015 May 4. PMID 25920570, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REPTOR and CREBRF encode key regulators of muscle energy metabolism.
      Title: REPTOR and CREBRF encode key regulators of muscle energy metabolism.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    repressed by TOR
    Names
    CG13624-PA
    CG13624-PB
    CG13624-PC
    CG13624-PD
    CG13624-PE
    CG13624-PF
    CG13624-PG
    REPTOR-PA
    REPTOR-PB
    REPTOR-PC
    REPTOR-PD
    REPTOR-PE
    REPTOR-PF
    REPTOR-PG

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24557368..24582864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170151.2 → NP_733013.1  repressed by TOR, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI17, Q8T9A9, Q9VC61
      UniProtKB/TrEMBL
      A0A0B4LHL0
      Related
      FBpp0084052
      Conserved Domains (1) summary
      cd14809
      Location:701 → 747
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    2. NM_170152.2 → NP_733014.1  repressed by TOR, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI17, Q8T9A9, Q9VC61
      UniProtKB/TrEMBL
      A0A0B4LHL0
      Related
      FBpp0084053
      Conserved Domains (1) summary
      cd14809
      Location:701 → 747
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    3. NM_001043287.2 → NP_001036752.1  repressed by TOR, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036752.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC61
      Conserved Domains (1) summary
      cd14809
      Location:701 → 756
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    4. NM_001043288.2 → NP_001036753.1  repressed by TOR, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VC61
      Conserved Domains (1) summary
      cd14809
      Location:701 → 756
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    5. NM_170150.2 → NP_733012.1  repressed by TOR, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI17, Q8T9A9, Q9VC61
      UniProtKB/TrEMBL
      A0A0B4LHL0
      Related
      FBpp0084054
      Conserved Domains (1) summary
      cd14809
      Location:701 → 747
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    6. NM_143014.3 → NP_651271.1  repressed by TOR, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651271.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI17, Q8T9A9, Q9VC61
      UniProtKB/TrEMBL
      A0A0B4LHL0
      Related
      FBpp0084055
      Conserved Domains (1) summary
      cd14809
      Location:701 → 747
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains

    7. NM_001300576.1 → NP_001287505.1  repressed by TOR, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KI17, Q8T9A9, Q9VC61
      UniProtKB/TrEMBL
      A0A0B4LHL0
      Conserved Domains (1) summary
      cd14809
      Location:701 → 747
      bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHL0 A0A0B4LHL0
    Q9VC61.2 Q9VC61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools