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    Flo1 Flotillin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36726, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flo1provided by FlyBase
    Official Full Name
    Flotillin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024754
    Locus tag
    Dmel_CG8200
    See related
    AllianceGenome:FB:FBgn0024754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8200; CK02126; dFlot1; Dmel\CG8200; flo; Flo; Flo-1; flo1; FLO1; Flot1; flotillin; Flo[Dm]; FLO[Dm]; FLO[Dm]-1; reggie-2
    Summary
    Predicted to enable protease binding activity. Predicted to be involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; protein kinase C signaling; and regulation of endocytosis. Located in cytoplasm. Is expressed in several structures, including ganglia; optic chiasma; sense organ; sensory cluster; and sensory nervous system primordium. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Flo1 in Genome Data Viewer
    Location:
    52A13-52A13; 2-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15566271..15569404, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11453776..11456909, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster. Galbiati F, et al. Gene, 1998 Apr 14. PMID 9573373
    2. Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter. Karam CS, et al. J Chem Neuroanat, 2017 Oct. PMID 28571709, Free PMC Article
    3. The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila. Pizzo AB, et al. Mol Psychiatry, 2013 Jul. PMID 22710269, Free PMC Article
    4. Computational identification of operon-like transcriptional loci in eukaryotes. Nannapaneni K, et al. Comput Biol Med, 2013 Jul. PMID 23668349
    5. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Ben-Shahar Y, et al. Proc Natl Acad Sci U S A, 2007 Jan 2. PMID 17190802, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell junction assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein kinase C signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of flotillin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of flotillin complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    flotillin 1
    Names
    CG8200-PA
    CG8200-PB
    Flo1-PA
    Flo1-PB
    Flotillin-1
    Flotillin1
    flotillin
    reggie2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15566271..15569404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058010.4 → NP_477358.1  flotillin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477358.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61491, Q9V7D7
      Related
      FBpp0086484
      Conserved Domains (2) summary
      COG2268
      Location:5 → 422
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:33 → 178
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

    2. NM_166102.2 → NP_725476.1  flotillin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61491
      Related
      FBpp0086485
      Conserved Domains (2) summary
      COG2268
      Location:5 → 426
      YqiK; Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown]
      cd03399
      Location:33 → 182
      SPFH_flotillin; Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O61491.1 O61491

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
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