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    Hmt-1 Heavy metal tolerance factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmt-1provided by FlyBase
    Official Full Name
    Heavy metal tolerance factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038376
    Locus tag
    Dmel_CG4225
    See related
    AllianceGenome:FB:FBgn0038376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCB6; CG4225; DmCG4225; Dmel\CG4225; EP(3)3387; hmt-1; HMT-1
    Summary
    Predicted to enable ABC-type heme transporter activity and heme binding activity. Involved in cellular detoxification of cadmium ion. Located in vacuolar membrane. Is expressed in adult head; adult heart; embryonic/larval midgut; gastric caecum; and organism. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Orthologous to human ABCB6 (ATP binding cassette subfamily B member 6 (LAN blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hmt-1 in Genome Data Viewer
    Location:
    89A6-89A6; 3-58 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15853868..15857470, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11679590..11683192, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene spindle E Neighboring gene PSEA-binding protein 45kD Neighboring gene crossveinless d Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. Sooksa-Nguan T, et al. J Biol Chem, 2009 Jan 2. PMID 19001374
    2. Mdr65 decreases toxicity of multiple insecticides in Drosophila melanogaster. Sun H, et al. Insect Biochem Mol Biol, 2017 Oct. PMID 28803989
    3. Metabolomic analysis of the selection response of Drosophila melanogaster to environmental stress: are there links to gene expression and phenotypic traits? Malmendal A, et al. Naturwissenschaften, 2013 May. PMID 23571708
    4. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article
    5. HSP90 as a global genetic modifier for male genital morphology in Drosophila melanogaster. Takahashi KH, et al. Evolution, 2018 Nov. PMID 30221481

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type heme transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of cadmium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heme transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    heavy metal tolerance factor 1
    Names
    CG4225-PA
    Hmt-1-PA
    NP_650503.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15853868..15857470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142246.3 → NP_650503.1  heavy metal tolerance factor 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650503.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VF20
      Related
      FBpp0082642
      Conserved Domains (4) summary
      cd03253
      Location:576 → 812
      ABCC_ATM1_transporter; ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C
      COG5265
      Location:314 → 811
      ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]
      pfam00664
      Location:255 → 530
      ABC_membrane; ABC transporter transmembrane region
      pfam16185
      Location:3 → 241
      MTABC_N; Mitochondrial ABC-transporter N-terminal five TM region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VF20 Q9VF20

    Gene LinkOut

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