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    LpR2 Lipophorin receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LpR2provided by FlyBase
    Official Full Name
    Lipophorin receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051092
    Locus tag
    Dmel_CG31092
    See related
    AllianceGenome:FB:FBgn0051092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31092; CG4823; CG4834; Dmel\CG31092; lpr2; Lpr2; Lpr2-E
    Summary
    Enables lipoprotein particle binding activity. Involved in several processes, including mushroom body development; receptor-mediated endocytosis; and transport across blood-brain barrier. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; female germline cell; ganglia; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See LpR2 in Genome Data Viewer
    Location:
    96E10-96F1; 3-89 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25698727..25740465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21524449..21566187, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase Neighboring gene long non-coding RNA:CR46102 Neighboring gene Lipophorin receptor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions. Wang S, et al. J Biol Chem, 2018 May 11. PMID 29559555, Free PMC Article
    2. Different mechanisms for selective transport of fatty acids using a single class of lipoprotein in Drosophila. Matsuo N, et al. J Lipid Res, 2019 Jul. PMID 31085629, Free PMC Article
    3. Lipophorin receptor 1 (LpR1) in Drosophila muscle influences life span by regulating mitochondrial aging. Kim AK, et al. Biochem Biophys Res Commun, 2021 Sep 3. PMID 34217014
    4. Lipophorin receptors regulate mushroom body development and complex behaviors in Drosophila. Rojo-Cortés F, et al. BMC Biol, 2022 Sep 7. PMID 36071487, Free PMC Article
    5. Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism. Parra-Peralbo E, et al. PLoS Genet, 2011 Feb 10. PMID 21347279, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activity-induced isoform-specific upregulation of Drosophila lipophorin receptors LpR1 and LpR2, are reported.
      Title: Transcriptional Regulation of Lipophorin Receptors Supports Neuronal Adaptation to Chronic Elevations of Activity.
    2. Recruitment of apolipoprotein lipid transfer particle to cell membranes is mediated by Lpr2.
      Title: Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake.
    3. lipophorin receptor 1 and 2 (lpr1 and lpr2) are essential for the efficient uptake and accumulation of neutral lipids by oocytes and cells of the imaginal discs
      Title: Drosophila lipophorin receptors mediate the uptake of neutral lipids in oocytes and imaginal disc cells by an endocytosis-independent mechanism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c25734985-25725884 mobile_element_type = transposon:roo{}1421

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipoprotein particle binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transport across blood-brain barrier IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipophorin receptor 2
    Names
    CG31092-PA
    CG31092-PB
    CG31092-PC
    CG31092-PD
    CG31092-PE
    CG31092-PF
    CG31092-PG
    CG31092-PH
    CG31092-PI
    LpR2-PA
    LpR2-PB
    LpR2-PC
    LpR2-PD
    LpR2-PE
    LpR2-PF
    LpR2-PG
    LpR2-PH
    LpR2-PI
    a2M-receptor-like

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25698727..25740465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104457.2 → NP_001097927.1  lipophorin receptor 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN57
      Conserved Domains (1) summary
      smart00192
      Location:235 → 267
      LDLa; Low-density lipoprotein receptor domain class A

    2. NM_001104456.2 → NP_001097926.1  lipophorin receptor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRC4
      Conserved Domains (5) summary
      smart00192
      Location:235 → 267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:717 → 760
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:564 → 594
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:277 → 313
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:527 → 562
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. NM_001104459.2 → NP_001097929.1  lipophorin receptor 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTZ6
      Conserved Domains (5) summary
      smart00192
      Location:33 → 65
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:514 → 557
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:361 → 391
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:239 → 273
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:324 → 359
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. NM_001104458.2 → NP_001097928.1  lipophorin receptor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU01
      Conserved Domains (5) summary
      smart00192
      Location:235 → 267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:717 → 760
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:564 → 594
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:277 → 313
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:527 → 562
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. NM_170239.4 → NP_733118.3  lipophorin receptor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733118.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBN2
      Conserved Domains (5) summary
      smart00192
      Location:235 → 267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:716 → 759
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:563 → 593
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:441 → 475
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:526 → 561
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    6. NM_001104460.2 → NP_001097930.1  lipophorin receptor 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRC7
      Conserved Domains (5) summary
      smart00192
      Location:235 → 267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:716 → 759
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:563 → 593
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:441 → 475
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:526 → 561
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    7. NM_001276042.1 → NP_001262971.1  lipophorin receptor 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ9
      Conserved Domains (5) summary
      smart00192
      Location:33 → 65
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:515 → 558
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:362 → 392
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:75 → 111
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:325 → 360
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    8. NM_001276041.1 → NP_001262970.1  lipophorin receptor 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH38
      Conserved Domains (5) summary
      smart00192
      Location:33 → 65
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:515 → 558
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:362 → 392
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:75 → 111
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:325 → 360
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    9. NM_176565.2 → NP_788742.1  lipophorin receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B77
      Related
      FBpp0084302
      Conserved Domains (5) summary
      smart00192
      Location:33 → 65
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:514 → 557
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:361 → 391
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:239 → 273
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:324 → 359
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGZ9 A0A0B4KGZ9
    A0A0B4KH38 A0A0B4KH38
    A8JRC4 A8JRC4
    A8JRC7 A8JRC7
    Q6NN57 Q6NN57
    Q7YTZ6 Q7YTZ6
    Q7YU01 Q7YU01
    Q86B77 Q86B77
    Q9VBN2 Q9VBN2

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