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    LpR2 Lipophorin receptor 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43105, updated on 9-Dec-2024

    Summary

    Official Symbol
    LpR2provided by FlyBase
    Official Full Name
    Lipophorin receptor 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0051092
    Locus tag
    Dmel_CG31092
    See related
    AllianceGenome:FB:FBgn0051092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31092; CG4823; CG4834; Dmel\CG31092; lpr2; Lpr2; Lpr2-E
    Summary
    Enables lipoprotein particle binding activity. Involved in several processes, including mushroom body development; receptor-mediated endocytosis; and transport across blood-brain barrier. Located in plasma membrane. Is expressed in several structures, including adult head; embryonic central brain neurons; female germline cell; ganglia; and nephrocyte. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LRP8 (LDL receptor related protein 8); LDLR (low density lipoprotein receptor); and VLDLR (very low density lipoprotein receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LpR2 in Genome Data Viewer
    Location:
    96E10-96F1; 3-89 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25698727..25740465, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21524449..21566187, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27 Neighboring gene Cardiolipin synthase Neighboring gene long non-coding RNA:CR46102 Neighboring gene Lipophorin receptor 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c25734985-25725884 mobile_element_type = transposon:roo{}1421

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipoprotein particle binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    lipophorin receptor 2
    Names
    CG31092-PA
    CG31092-PB
    CG31092-PC
    CG31092-PD
    CG31092-PE
    CG31092-PF
    CG31092-PG
    CG31092-PH
    CG31092-PI
    LpR2-PA
    LpR2-PB
    LpR2-PC
    LpR2-PD
    LpR2-PE
    LpR2-PF
    LpR2-PG
    LpR2-PH
    LpR2-PI
    a2M-receptor-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25698727..25740465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104457.2NP_001097927.1  lipophorin receptor 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097927.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN57
      Conserved Domains (1) summary
      smart00192
      Location:235267
      LDLa; Low-density lipoprotein receptor domain class A
    2. NM_001104456.2NP_001097926.1  lipophorin receptor 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097926.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRC4
      Conserved Domains (5) summary
      smart00192
      Location:235267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:717760
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:564594
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:277313
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:527562
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. NM_001104459.2NP_001097929.1  lipophorin receptor 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YTZ6
      Conserved Domains (5) summary
      smart00192
      Location:3365
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:514557
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:361391
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:239273
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:324359
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    4. NM_001104458.2NP_001097928.1  lipophorin receptor 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU01
      Conserved Domains (5) summary
      smart00192
      Location:235267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:717760
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:564594
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:277313
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:527562
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    5. NM_170239.4NP_733118.3  lipophorin receptor 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733118.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBN2
      Conserved Domains (5) summary
      smart00192
      Location:235267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:716759
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:563593
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:441475
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:526561
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    6. NM_001104460.2NP_001097930.1  lipophorin receptor 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097930.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JRC7
      Conserved Domains (5) summary
      smart00192
      Location:235267
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:716759
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:563593
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:441475
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:526561
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    7. NM_001276042.1NP_001262971.1  lipophorin receptor 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ9
      Conserved Domains (5) summary
      smart00192
      Location:3365
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:515558
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:362392
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:75111
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:325360
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    8. NM_001276041.1NP_001262970.1  lipophorin receptor 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH38
      Conserved Domains (5) summary
      smart00192
      Location:3365
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:515558
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:362392
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:75111
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:325360
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    9. NM_176565.2NP_788742.1  lipophorin receptor 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788742.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86B77
      Related
      FBpp0084302
      Conserved Domains (5) summary
      smart00192
      Location:3365
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:514557
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:361391
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:239273
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam14670
      Location:324359
      FXa_inhibition; Coagulation Factor Xa inhibitory site