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    Pex11ab Peroxin 11a/b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex11abprovided by FlyBase
    Official Full Name
    Peroxin 11a/bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034058
    Locus tag
    Dmel_CG8315
    See related
    AllianceGenome:FB:FBgn0034058
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8315; DmelPex11; Dmel\CG8315; Pex11; PEX11A; PEX11A/B; PEX11B
    Summary
    Involved in peroxisome organization. Located in peroxisome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in peroxisome biogenesis disorder 14B. Orthologous to several human genes including PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pex11ab in Genome Data Viewer
    Location:
    52D9-52D9; 2-76 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15991367..15992375, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11878872..11879880, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Stretchin-Mlck Neighboring gene long non-coding RNA:CR45021 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ATP citrate lyase Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila toolkit for HA-tagged proteins unveils a block in autophagy flux in the last instar larval fat body. Murakawa T, et al. Development, 2022 Mar 15. PMID 35319746
    2. Recruitment of Peroxin 14 to lipid droplets affects lipid storage in Drosophila. Ueda K, et al. J Cell Sci, 2022 Apr 1. PMID 35274690
    3. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. Chen H, et al. Hum Mol Genet, 2010 Feb 1. PMID 19933170
    4. A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. Mast FD, et al. Dis Model Mech, 2011 Sep. PMID 21669930, Free PMC Article
    5. Autocrine insulin pathway signaling regulates actin dynamics in cell wound repair. Nakamura M, et al. PLoS Genet, 2020 Dec. PMID 33306674, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peroxin 11a/b
    Names
    CG8315-PA
    Pex11ab-PA
    peroxin 11

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15991367..15992375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137227.3 → NP_611071.1  peroxin 11a/b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZE1
      Related
      FBpp0086405
      Conserved Domains (1) summary
      pfam05648
      Location:1 → 232
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZE1 Q7JZE1

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