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    dock dreadlocks [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dockprovided by FlyBase
    Official Full Name
    dreadlocksprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010583
    Locus tag
    Dmel_CG3727
    See related
    AllianceGenome:FB:FBgn0010583
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2L19; CG3727; dck; Dm0447; Dmel\CG3727; doc; Dock; DOCK; l(2)04723; Nck
    Summary
    Enables several functions, including cell adhesion molecule binding activity; insulin receptor binding activity; and protein kinase binding activity. Involved in axon guidance; myoblast fusion; and negative regulation of insulin receptor signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic myoblast; embryonic/larval midgut primordium; ganglia; mesoderm; and presumptive embryonic/larval system. Orthologous to several human genes including NCK2 (NCK adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dock in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (825969..833241)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (825969..833241)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Clipper Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene drongo Neighboring gene long non-coding RNA:CR44060 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting Nck/Dock signaling pathways in Drosophila visual system. Rao Y. Int J Biol Sci, 2005. PMID 15951852, Free PMC Article
    2. Direct Phosphorylation of SRC Homology 3 Domains by Tyrosine Kinase Receptors Disassembles Ligand-Induced Signaling Networks. Dionne U, et al. Mol Cell, 2018 Jun 21. PMID 29910111, Free PMC Article
    3. Domain requirements for the Dock adapter protein in growth- cone signaling. Rao Y, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482841, Free PMC Article
    4. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Garrity PA, et al. Cell, 1996 May 31. PMID 8646773
    5. The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events. McCarty JH. Bioessays, 1998 Nov. PMID 9872057

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
      Title: Differential regulation of protein tyrosine kinase signalling by Dock and the PTP61F variants.
    2. Study propose that Dock links cell adhesion in FCs and FCMs with either Scar- or Vrp1-WASp-dependent Arp2/3 activation.
      Title: Dock mediates Scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts.
    3. Data indicate that Activated Cdc42 kinase Ack forms a complex with dreadlocks via its SH2 domain.
      Title: Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis.
    4. Studies reveal for the first time that the adaptor protein Dock/Nck attenuates insulin signalling by recruiting PTP61F/PTP1B to its substrate, the IR.
      Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
    5. The Nck/Dock SH2/SH3 adapter protein plays a role in photoreceptor (R cell) axon guidance and target recognition in the Drosophila visual system.It mediates between cell surface receptors and the actin cytoskeleton. Review.
      Title: Dissecting Nck/Dock signaling pathways in Drosophila visual system.
    6. exogenous expression of mouse Dab1 causes tyrosine phosphorylation site-dependent morphology changes in the compound eye; phenotype enhanced by overexpression of the Nck protein Dock; suggests a conserved interaction between Disabled & Nck family members
      Title: Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.
    7. Dock regulates olfactory axon pathfinding in Drosophila
      Title: Dock and Pak regulate olfactory axon pathfinding in Drosophila.
    8. Drosophila insulin receptor functions as a guidance receptor for the adapter protein Dock/Nck
      Title: Axons guided by insulin receptor in Drosophila visual system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dreadlocks
    Names
    CG3727-PA
    CG3727-PB
    CG3727-PC
    CG3727-PD
    dock
    dock-PA
    dock-PB
    dock-PC
    dock-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      825969..833241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057628.4 → NP_476976.1  dreadlocks, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476976.1

      Status: REVIEWED

      Related
      FBpp0077678
      Conserved Domains (4) summary
      cd09943
      Location:308 → 400
      SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
      cd11765
      Location:16 → 66
      SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
      cd11766
      Location:118 → 170
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11767
      Location:190 → 245
      SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

    2. NM_164389.2 → NP_722657.1  dreadlocks, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24218, Q8IPW2, Q9VPU1
      Related
      FBpp0077679
      Conserved Domains (4) summary
      cd09943
      Location:446 → 538
      SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
      cd11765
      Location:154 → 204
      SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
      cd11766
      Location:256 → 308
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11767
      Location:328 → 383
      SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

    3. NM_164390.2 → NP_722658.1  dreadlocks, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722658.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24218, Q8IPW2, Q9VPU1
      Related
      FBpp0077680
      Conserved Domains (4) summary
      cd09943
      Location:446 → 538
      SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
      cd11765
      Location:154 → 204
      SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
      cd11766
      Location:256 → 308
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11767
      Location:328 → 383
      SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins

    4. NM_001272916.1 → NP_001259845.1  dreadlocks, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259845.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24218, Q8IPW2, Q9VPU1
      Conserved Domains (4) summary
      cd09943
      Location:446 → 538
      SH2_Nck_family; Src homology 2 (SH2) domain found in the Nck family
      cd11765
      Location:154 → 204
      SH3_Nck_1; First Src Homology 3 domain of Nck adaptor proteins
      cd11766
      Location:256 → 308
      SH3_Nck_2; Second Src Homology 3 domain of Nck adaptor proteins
      cd11767
      Location:328 → 383
      SH3_Nck_3; Third Src Homology 3 domain of Nck adaptor proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24218 Q24218
    Q8IPW2 Q8IPW2
    Q9VPU1 Q9VPU1

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