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    Ddx56 DEAD-box helicase 56 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddx56provided by FlyBase
    Official Full Name
    DEAD-box helicase 56provided by FlyBase
    Primary source
    FLYBASE:FBgn0001565
    Locus tag
    Dmel_CG1666
    See related
    AllianceGenome:FB:FBgn0001565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    11P1; 14; 7; A112; CG1666; dDDX56; Dmel\CG1666; DmRH10; hlc; Hlc; HLC; HM-44; l(1)11P1; l(1)19Ff; l(1)8-1; l(1)A112; l(1)S-19F6; l11P1; lA112
    Summary
    Predicted to enable RNA helicase activity. Involved in defense response to virus. Predicted to be located in cytosol. Predicted to be active in nucleolus. Is expressed in brain; embryonic/larval fat body; embryonic/larval salivary gland; imaginal disc; and ovary. Orthologous to human DDX56 (DEAD-box helicase 56). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ddx56 in Genome Data Viewer
    Location:
    20A1-20A1; 1-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21385518..21387946, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21256545..21258973, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene waclaw Neighboring gene bobby sox Neighboring gene antisense RNA:CR45612 Neighboring gene antisense RNA:CR45611 Neighboring gene sluggish A Neighboring gene ncRNA Neighboring gene misato Neighboring gene la costa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Schizosaccharomyces pombe mgU6-47 gene is required for 2'-O-methylation of U6 snRNA at A41. Zhou H, et al. Nucleic Acids Res, 2002 Feb 15. PMID 11842100, Free PMC Article
    2. The DEAD-box helicase DDX56 is a conserved stemness regulator in normal and cancer stem cells. Pryszlak M, et al. Cell Rep, 2021 Mar 30. PMID 33789112
    3. An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tubulin-like and myosin-like peptide motifs. Miklos GL, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144213, Free PMC Article
    4. The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis. Hayward DC, et al. Proc Natl Acad Sci U S A, 1993 Apr 1. PMID 8096642, Free PMC Article
    5. DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs. Hyun J, et al. Mol Cell Biol, 2005 Jul. PMID 15964814, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes.
      Title: The DEAD-box helicase Hlc regulates basal transcription and chromatin opening of stress-responsive genes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_negative_effect modulation by host of viral RNA genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DEAD-box helicase 56
    Names
    CG1666-PA
    CG1666-PB
    Ddx56-PA
    Ddx56-PB
    RNA helicase gene
    helicase
    lethal(1)19Ff
    section 14
    section 7
    NP_001285517.1
    NP_523434.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21385518..21387946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078710.4 → NP_523434.2  DEAD-box helicase 56, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523434.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61350, Q9VRI0
      Related
      FBpp0076917
      Conserved Domains (3) summary
      smart00487
      Location:24 → 231
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:234 → 386
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:11 → 220
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001298588.1 → NP_001285517.1  DEAD-box helicase 56, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61350, Q9VRI0
      Conserved Domains (3) summary
      smart00487
      Location:24 → 231
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:234 → 386
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:11 → 220
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYS0 Q8MYS0
    Q9VRI0 Q9VRI0

    Gene LinkOut

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