Pgant35A Polypeptide N-acetylgalactosaminyltransferase 35A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pgant35Aprovided by FlyBase
Official Full Name: Polypeptide N-acetylgalactosaminyltransferase 35Aprovided by FlyBase
Primary source: FLYBASE:FBgn0001970
Locus tag: Dmel_CG7480
See related: AllianceGenome:FB:FBgn0001970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A3; BG:DS01068.8; br12; CG7480; dGalNAc-T1; Dmel\CG7480; GalNAc-T; l(2)35Aa; l(2)br12; l35Aa; pgant35; pgant35A; Pgant35a; ppGalNAcT35A
Summary: Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process and open tracheal system development. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; embryonic/larval hindgut; embryonic/larval midgut primordium; gonad; and imaginal disc. Orthologous to several human genes including GALNT11 (polypeptide N-acetylgalactosaminyltransferase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (14359252..14361411)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (14359252..14361411)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Drosophila embryogenesis requires functional pgant35A; the presence of this gene product during fly embryogenesis is functionally distinct from other Drosophila GalNAc-transferase isoforms and from the proposed human ortholog GALNT11.
Title: Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11.
essential for viability in Drosophila melanogaster
Title: A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is essential for viability in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables polypeptide N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein O-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi stack	NAS Non-traceable Author Statement more info	PubMed

Names: CG7480-PA; Pgant35A-PA; lethal 12 in the black-reduced region; lethal group A3

NP_652069.2

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