hyd hyperplastic discs [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hydprovided by FlyBase
Official Full Name: hyperplastic discsprovided by FlyBase
Primary source: FLYBASE:FBgn0002431
Locus tag: Dmel_CG9484
See related: AllianceGenome:FB:FBgn0002431
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: c43; CG9484; Dmel\CG9484; Hyd; HYD; l(3)85Ea; l(3)c43; l(3)C43; l(3)C43-3; l(3)SG33; l[[3]]c43; NP_524296.2; UBE 3A; Ubr5; UBR5
Summary: Enables ubiquitin protein ligase activity. Involved in several processes, including imaginal disc growth; male meiosis cytokinesis; and positive regulation of signal transduction. Located in cytoplasm and nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in breast cancer (multiple) and carcinoma (multiple). Orthologous to human UBR5 (ubiquitin protein ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85E5-85E5; 3-49 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9714623..9725615, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5540345..5551337, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
Title: Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis.
[Functions of E3 Ubiquitin Ligase Hyd in Drosophila Tissues].
Title: [Functions of E3 Ubiquitin Ligase Hyd in Drosophila Tissues].
UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
Title: UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis.
Hyd mediated Lys63 (K63)-linked polyubiquitination of the NF-kappaB cofactor Akirin was required for efficient binding of Akirin to the NF-kappaB transcription factor Relish.
Title: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila.
Wnt-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase Hyd/UBR5 is a key prerequisite that enables Armadillo/beta-catenin to activate transcription.
Title: Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.
Drosophila-based findings highlight an apical role for Hyd and Sgg in initiating Hedgehog signalling, which could also be evolutionarily conserved in mammals
Title: Regulation of hedgehog Ligand Expression by the N-End Rule Ubiquitin-Protein Ligase Hyperplastic Discs and the Drosophila GSK3β Homologue, Shaggy.
hyperplastic discs (hyd), an E3 ubiquitin ligase, can differentially regulate the transcriptional outputs of Hh signaling. We show that loss of Hyd activity caused upregulation of some, but not all of Hh target genes.
Title: Hyperplastic discs differentially regulates the transcriptional outputs of hedgehog signaling.
data document that, in addition to the tumour suppressor Merlin, another tumour suppressor, Hyd, also has a function in spermatogenesis
Title: The role of Drosophila hyperplastic discs gene in spermatogenesis.
hyperplastic discs encodes a HECT domain E3 ubiquitin ligase that is likely to act by targeting Cubitus interruptus and an unknown activator of hedgehog expression for proteolysis
Title: The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-ubiquitin ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in eye-antennal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K48-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K63-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in spermatid nucleus differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hyperplastic discs

Names: CG9484-PA; CG9484-PB; hyd-PA; hyd-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9714623..9725615 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079572.4 → NP_524296.2 hyperplastic discs, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524296.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P51592, Q9VH88

UniProtKB/TrEMBL

A0A0H4Y1G5

Related

FBpp0081568

Conserved Domains (5) summary

smart00396
Location:1217 → 1284

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2496 → 2559

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2587 → 2882

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam11547
Location:150 → 196

E3_UbLigase_EDD; E3 ubiquitin ligase EDD

NF033845
Location:1570 → 1742

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
NM_001300333.1 → NP_001287262.1 hyperplastic discs, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287262.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGZ6

Conserved Domains (6) summary

smart00396
Location:1217 → 1284

ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway

smart00517
Location:2498 → 2561

PolyA; C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein

smart00119
Location:2589 → 2884

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:2589 → 2885

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

pfam11547
Location:150 → 196

E3_UbLigase_EDD; E3 ubiquitin ligase EDD

cl22451
Location:1535 → 1733

ASF1_hist_chap; ASF1 like histone chaperone