U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Su(z)2 Suppressor of zeste 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36432, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Su(z)2provided by FlyBase
    Official Full Name
    Suppressor of zeste 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0265623
    Locus tag
    Dmel_CG3905
    See related
    AllianceGenome:FB:FBgn0265623
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Arp; CG3905; Dmel\CG3905; l(2)k06344; su(z)2; Su(Z)2; SU(Z)2; Su(z)2D; su(z)3; Su(z)3; Su(z)[[2]]; Suz2; SUZ2
    Summary
    Enables DNA binding activity. Involved in heterochromatin formation. Located in nucleus. Part of PRC1 complex. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Su(z)2 in Genome Data Viewer
    Location:
    49E7-49E7; 2-67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12996501..13007911)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8884006..8895416)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44339 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2. Nguyen SC, et al. Genetics, 2017 Feb. PMID 27881472, Free PMC Article
    2. Adhesive pad differentiation in Drosophila melanogaster depends on the Polycomb group gene Su(z)2. Hüsken M, et al. J Exp Biol, 2015 Apr 15. PMID 25714570
    3. The sequence of the Drosophila regulatory gene Suppressor two of zeste. Brunk BP, et al. Nucleic Acids Res, 1991 Jun 11. PMID 2057369, Free PMC Article
    4. Transcriptional repression mediated by polycomb group proteins and other chromatin-associated repressors is selectively blocked by insulators. van der Vlag J, et al. J Biol Chem, 2000 Jan 7. PMID 10617669
    5. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Brunk BP, et al. Nature, 1991 Sep 26. PMID 1833647

    See all (211) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in Su(z)2 increase fly survival. This protein influences on Life Span via pathways independent of its Polycomb Repressive Complex 1 functions, with distinct effects on response to Oxidative Stress.
      Title: Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster.
    2. Core activity of Su(z)2 seems to reside in the N-terminal homology region. C-terminal region is dispensable for viability. Data also suggest a regulatory cascade between C-terminus and homology region.
      Title: An Unexpected Regulatory Cascade Governs a Core Function of the Drosophila PRC1 Chromatin Protein Su(z)2.
    3. Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
      Title: Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
    4. The Psc-Su(z)2 locus is flanked by insulator elements that may protect neighboring genes from inappropriate silencing.
      Title: Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster.
    5. Posterior sex combs (Psc), which encodes a core Polycomb-repressive complex 1 (PRC1) component, functions redundantly with a similar gene, Suppressor of zeste two [Su(z)2], to restrict follicle stem cell (FSC) self-renewal in the Drosophila ovary
      Title: Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling.
    6. results establish Suppressor 2 of zeste as a functional homolog of Posterior Sex Combs and suggest that the two proteins operate via similar molecular mechanisms
      Title: Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    suppressor of zeste 2
    Names
    CG3905-PA
    CG3905-PB
    CG3905-PC
    Su(z)2-PA
    Su(z)2-PB
    Su(z)2-PC
    aristapedioid
    aristopedoid
    suppressor 2 of zeste
    suppressor of zeste (2)
    suppressor of zeste (3)
    suppressor of zeste 3
    suppressor of zeste two
    suppressor two of zeste
    supressor of zeste 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12996501..13007911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169663.3 → NP_001163134.1  suppressor of zeste 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25172, Q9V6J0
      UniProtKB/TrEMBL
      E1JH51, H6QXK0, H6QXK1
      Conserved Domains (2) summary
      pfam00097
      Location:35 → 73
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:143 → 228
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    2. NM_001274004.1 → NP_001260933.1  suppressor of zeste 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEM5, H6QXK0, H6QXK1
      Conserved Domains (2) summary
      pfam00097
      Location:35 → 73
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:143 → 228
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    3. NM_079002.3 → NP_523726.2  suppressor of zeste 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523726.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25172, Q9V6J0
      UniProtKB/TrEMBL
      E1JH51, H6QXK0, H6QXK1
      Related
      FBpp0086906
      Conserved Domains (2) summary
      pfam00097
      Location:35 → 73
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:143 → 228
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEM5 A0A0B4KEM5
    E1JH51 E1JH51
    P25172.2 P25172

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools