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    Nca Neurocalcin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40186, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ncaprovided by FlyBase
    Official Full Name
    Neurocalcinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013303
    Locus tag
    Dmel_CG7641
    See related
    AllianceGenome:FB:FBgn0013303
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7641; Dmel\CG7641; nca; Ncalc
    Summary
    Enables calcium ion binding activity. Involved in negative regulation of neuronal signal transduction and positive regulation of circadian sleep/wake cycle, sleep. Is expressed in adult head. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to several human genes including NCALD (neurocalcin delta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nca in Genome Data Viewer
    Location:
    76D8-76D8; 3-46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19991887..19997568)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19984987..19990668)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene schumacher-levy Neighboring gene antisense RNA:CR45161 Neighboring gene CMP-sialic acid synthase Neighboring gene flightin Neighboring gene uncharacterized protein Neighboring gene gamma-aminobutyric acid transaminase Neighboring gene Translocase of outer membrane 20 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila neurocalcin, a fatty acylated, Ca2+-binding protein that associates with membranes and inhibits in vitro phosphorylation of bovine rhodopsin. Faurobert E, et al. J Biol Chem, 1996 Apr 26. PMID 8626592
    2. A highly conserved homologue of bovine neurocalcin in Drosophila melanogaster is a Ca(2+)-binding protein expressed in neuronal tissues. Teng DH, et al. J Biol Chem, 1994 Dec 16. PMID 7989365
    3. Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function. Braunewell KH, et al. Cell Tissue Res, 1999 Jan. PMID 9931348
    4. Fast inactivation of Shal (K(v)4) K+ channels is regulated by the novel interactor SKIP3 in Drosophila neurons. Diao F, et al. Mol Cell Neurosci, 2009 Sep. PMID 19463952, Free PMC Article
    5. Neurocalcin regulates nighttime sleep and arousal in Drosophila. Chen KF, et al. Elife, 2019 Mar 13. PMID 30865587, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of neuronal signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurocalcin
    Names
    CG7641-PA
    Frequenin3
    Nca-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19991887..19997568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176365.3 → NP_788543.1  neurocalcin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42325, Q9VW67
      Related
      FBpp0074671
      Conserved Domains (1) summary
      COG5126
      Location:13 → 179
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42325.2 P42325

    Gene LinkOut

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