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    retn retained [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45976, updated on 9-Dec-2024

    Summary

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    Official Symbol
    retnprovided by FlyBase
    Official Full Name
    retainedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004795
    Locus tag
    Dmel_CG5403
    See related
    AllianceGenome:FB:FBgn0004795
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2535; BcDNA:LD35748; CG5403; Dead Ringer/Retain; Dmel\CG5403; dri; Dri; DRI; EHMT; EY2-10; l(2)02535; Retn; retn/dri
    Summary
    Enables DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including neurogenesis; regulation of DNA-templated transcription; and regulation of female receptivity. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; ganglia; gut section; mesoderm; and neurohemal organ. Orthologous to several human genes including ARID3A (AT-rich interaction domain 3A) and ARID3C (AT-rich interaction domain 3C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See retn in Genome Data Viewer
    Location:
    59F5-59F5; 2-104 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23632610..23654820)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19520133..19542343)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Entomoglyceroporin 2 Neighboring gene Entomoglyceroporin 3 Neighboring gene Entomoglyceroporin 4 Neighboring gene long non-coding RNA:CR45153 Neighboring gene Phosphodiesterase 8 Neighboring gene Sulfotransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compensating increases in protein backbone flexibility occur when the Dead ringer AT-rich interaction domain (ARID) binds DNA: a nitrogen-15 relaxation study. Iwahara J, et al. Protein Sci, 2005 May. PMID 15802641, Free PMC Article
    2. The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA. Iwahara J, et al. EMBO J, 2002 Mar 1. PMID 11867548, Free PMC Article
    3. Solution structure of the DNA binding domain from Dead ringer, a sequence-specific AT-rich interaction domain (ARID). Iwahara J, et al. EMBO J, 1999 Nov 1. PMID 10545119, Free PMC Article
    4. The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity. Dallas PB, et al. Mol Cell Biol, 2000 May. PMID 10757798, Free PMC Article
    5. Characterization of the dead ringer gene identifies a novel, highly conserved family of sequence-specific DNA-binding proteins. Gregory SL, et al. Mol Cell Biol, 1996 Mar. PMID 8622680, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors
      Title: Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors.
    2. RETN has a role in Drosophila preblastoderm syncytial mitoses
      Title: The Drosophila retained/dead ringer gene and ARID gene family function during development.
    3. Dead ringer's preference for AT-rich DNA originates from three positions within the ARID fold that form energetically significant contacts to an adenine-thymine base step.
      Title: The structure of the Dead ringer-DNA complex reveals how AT-rich interaction domains (ARIDs) recognize DNA.
    4. three genes, dead ringer (dri), Serrate (Ser), and trh itself, are expressed in the embryonic salivary duct independently of trh
      Title: Specification of cell fates within the salivary gland primordium.
    5. Data suggest that Drosphila dead ringer is an important regulator of the late development of longitudinal glia.
      Title: The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gliogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in oogenesis HMP PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of female receptivity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in salivary gland development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    retained
    Names
    CG5403-PA
    CG5403-PB
    CG5403-PC
    CG5403-PD
    CG5403-PE
    dead Ringer/Retain
    dead ringer
    dead-ringer
    retn-PA
    retn-PB
    retn-PC
    retn-PD
    retn-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23632610..23654820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176254.2 → NP_788434.1  retained, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788434.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24573, Q8MSB0, Q9W1M0
      Related
      FBpp0071982
      Conserved Domains (1) summary
      smart00501
      Location:294 → 386
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    2. NM_057516.4 → NP_476864.2  retained, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476864.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24573
      Related
      FBpp0071981
      Conserved Domains (1) summary
      smart00501
      Location:289 → 381
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    3. NM_001299846.1 → NP_001286775.1  retained, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGB3
      Conserved Domains (1) summary
      smart00501
      Location:37 → 129
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    4. NM_001299844.1 → NP_001286773.1  retained, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGF9
      Conserved Domains (1) summary
      smart00501
      Location:287 → 379
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain

    5. NM_001299845.1 → NP_001286774.1  retained, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286774.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHB8
      Conserved Domains (1) summary
      smart00501
      Location:18 → 110
      BRIGHT; BRIGHT, ARID (A/T-rich interaction domain) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGB3 A0A0B4LGB3
    A0A0B4LGF9 A0A0B4LGF9
    A0A0B4LHB8 A0A0B4LHB8
    Q24573.2 Q24573

    Gene LinkOut

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