mof males absent on the first [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mofprovided by FlyBase
Official Full Name: males absent on the firstprovided by FlyBase
Primary source: FLYBASE:FBgn0014340
Locus tag: Dmel_CG3025
See related: AllianceGenome:FB:FBgn0014340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3025; Dmel\CG3025; dmMOF; dMOF; max; Mof; MOF
Summary: Enables chromatin binding activity; histone H4K16 acetyltransferase activity; and lncRNA binding activity. Involved in DNA damage response, signal transduction by p53 class mediator; chromatin remodeling; and positive regulation of DNA-templated transcription. Located in X chromosome; nuclear chromosome; and polytene chromosome interband. Part of chromatin and transcription regulator complex. Is expressed in organism. Orthologous to human KAT8 (lysine acetyltransferase 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 5C5-5C5; 1-14 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5873840..5876853, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5767873..5770886, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Accumulation of Mof at the Diap1 promoter 800 bp upstream of the transcription start site in wild type larvae is significantly higher (up to two folds) compared to mof1 mutants.
Title: Drosophila MOF regulates DIAP1 and induces apoptosis in a JNK dependent pathway.
MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.
Title: Drosophila MOF controls Checkpoint protein2 and regulates genomic stability during early embryogenesis.
The role of MOF in the response to ionizing radiation is conserved between Drosophila and mammals.
Title: The role of MOF in the ionizing radiation response is conserved in Drosophila melanogaster.
It was shown that the MOF chromobarrel domain is essential for H4K16 acetylation throughout the Drosophila genome and is required for spreading of the male-specific lethal complex on the X chromosome.
Title: The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex.
The activation potential of MOF is constrained in male cells in the context of the DCC to arrive at the 2-fold activation of transcription characteristic of dosage compensation.
Title: The activation potential of MOF is constrained for dosage compensation.
MOF is not only involved in the onset of dosage compensation, but also acts as a regulator of gene expression in the Drosophila genome.
Title: Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila.
MOF is an essential factor for embryogenesis and oncogenesis
Title: The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis.
The roX1 and roX2 genes produce redundant, male-specific lethal transcripts required for targeting the MSL complex.
Title: The roX genes encode redundant male-specific lethal transcripts required for targeting of the MSL complex.
Data show that the non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes.
Title: The non-dosage compensated Lsp1alpha gene of Drosophila melanogaster escapes acetylation by MOF in larval fat body nuclei, but is flanked by two dosage compensated genes.
chromo barrel domain structure from the MOF acetyltransferase
Title: Structure of the chromo barrel domain from the MOF acetyltransferase.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K16 acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H4K16 acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4K16 acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone acetyltransferase activity	TAS Traceable Author Statement more info	PubMed
enables lncRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair-dependent chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dosage compensation by hyperactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed
involved_in dosage compensation by hyperactivation of X chromosome	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression, epigenetic	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in sex-chromosome dosage compensation	IDA Inferred from Direct Assay more info	PubMed
involved_in sex-chromosome dosage compensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sex-chromosome dosage compensation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MSL complex	IDA Inferred from Direct Assay more info	PubMed
part_of NSL complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NSL complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in X chromosome	TAS Traceable Author Statement more info	PubMed
part_of X chromosome located dosage compensation complex, transcription activating	IDA Inferred from Direct Assay more info	PubMed
part_of X chromosome located dosage compensation complex, transcription activating	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome interband	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: males absent on the first

Names: CG3025-PA; MOF histone acetylase; males absent on first; males-absent on the X; males-absent-on-the-first; mof-PA

NP_511051.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5873840..5876853 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078496.3 → NP_511051.1 males absent on the first [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511051.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8B845, A8B850, A8B854, A8B859, A8B879, A8B889, A8B895, A8B8A1, A8ILB7, A8ILC1, A8ILC8, A8ILD1, A8ILD6, A8ILE1, A8ILE5, O02193, Q9W463

UniProtKB/TrEMBL

I1V4X5

Related

FBpp0070794

Conserved Domains (3) summary

pfam01853
Location:599 → 778

MOZ_SAS; MOZ/SAS family

pfam11717
Location:382 → 432

Tudor-knot; RNA binding activity-knot of a chromodomain

cl17182
Location:528 → 813

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate