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    Rfx Rfx [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41266, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rfxprovided by FlyBase
    Official Full Name
    Rfxprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020379
    Locus tag
    Dmel_CG6312
    See related
    AllianceGenome:FB:FBgn0020379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6312; Dmel\CG6312; dRfx; dRFX; rfx; RFX
    Summary
    Enables sequence-specific DNA binding activity. Involved in nervous system development and sensory perception of sound. Is expressed in several structures, including brain; embryonic segment; imaginal disc; peripheral sensory precursor cell; and sensory nervous system primordium. Orthologous to several human genes including RFX3 (regulatory factor X3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rfx in Genome Data Viewer
    Location:
    86B1-86B2; 3-49 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10361760..10378068, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6187482..6203790, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene jumeau Neighboring gene long non-coding RNA:CR44938 Neighboring gene clockwork orange

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila regulatory factor X is an embryonic type I sensory neuron marker also expressed in spermatids and in the brain of Drosophila. Vandaele C, et al. Mech Dev, 2001 May. PMID 11335126
    2. hemingway is required for sperm flagella assembly and ciliary motility in Drosophila. Soulavie F, et al. Mol Biol Cell, 2014 Apr. PMID 24554765, Free PMC Article
    3. Cloning and characterization of dRFX, the Drosophila member of the RFX family of transcription factors. Durand B, et al. Gene, 2000 Apr 4. PMID 10767550
    4. Mutations in ZMYND10, a gene essential for proper axonemal assembly of inner and outer dynein arms in humans and flies, cause primary ciliary dyskinesia. Moore DJ, et al. Am J Hum Genet, 2013 Aug 8. PMID 23891471, Free PMC Article
    5. Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation. Dubruille R, et al. Development, 2002 Dec. PMID 12403718

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It was shown that fd3F is required for specialization of the mechanosensory cilium of chordotonal neurons. Fd3F cooperates with the panciliary transcription factor, Rfx, to regulate its targets directly.
      Title: Forkhead transcription factor Fd3F cooperates with Rfx to regulate a gene expression program for mechanosensory cilia specialization.
    2. an essential regulator of ciliated sensory neuron differentiation in Drosophila
      Title: Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rfx
    Names
    CG6312-PC
    CG6312-PF
    CG6312-PG
    CG6312-PH
    CG6312-PI
    CG6312-PJ
    Rfx-PC
    Rfx-PF
    Rfx-PG
    Rfx-PH
    Rfx-PI
    Rfx-PJ
    regulatory factor X

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10361760..10378068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260092.2 → NP_001247021.1  Rfx, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247021.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6P1, Q9U1K2
      Conserved Domains (1) summary
      pfam02257
      Location:385 → 458
      RFX_DNA_binding; RFX DNA-binding domain

    2. NM_141742.3 → NP_649999.2  Rfx, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649999.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K2, Q9VGZ6
      Related
      FBpp0308021
      Conserved Domains (1) summary
      pfam02257
      Location:371 → 444
      RFX_DNA_binding; RFX DNA-binding domain

    3. NM_001260094.2 → NP_001247023.2  Rfx, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247023.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K653, Q9U1K2
      Conserved Domains (1) summary
      pfam02257
      Location:393 → 466
      RFX_DNA_binding; RFX DNA-binding domain

    4. NM_001275535.1 → NP_001262464.1  Rfx, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262464.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFL4
      Conserved Domains (1) summary
      pfam02257
      Location:356 → 429
      RFX_DNA_binding; RFX DNA-binding domain

    5. NM_001104268.2 → NP_001097738.2  Rfx, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097738.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8JQX0, Q9U1K2
      Conserved Domains (1) summary
      pfam02257
      Location:363 → 436
      RFX_DNA_binding; RFX DNA-binding domain

    6. NM_001260093.2 → NP_001247022.2  Rfx, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247022.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K621
      Conserved Domains (1) summary
      pfam02257
      Location:334 → 407
      RFX_DNA_binding; RFX DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K621 A0A0B4K621
    A0A0B4K653 A0A0B4K653
    A0A0B4K6P1 A0A0B4K6P1
    A0A0B4KFL4 A0A0B4KFL4
    A8JQX0 A8JQX0
    Q9U1K2 Q9U1K2
    Q9VGZ6 Q9VGZ6

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