org-1 optomotor-blind-related-gene-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: org-1provided by FlyBase
Official Full Name: optomotor-blind-related-gene-1provided by FlyBase
Primary source: FLYBASE:FBgn0021767
Locus tag: Dmel_CG11202
See related: AllianceGenome:FB:FBgn0021767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11202; Dm-ORG-1; Dmel\CG11202; Org-1; org1
Summary: Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II and somatic muscle development. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including embryonic somatic muscle cell; larval muscle cell; somatic mesoderm; trunk mesoderm; and visceral mesoderm. Human ortholog(s) of this gene implicated in several diseases, including DiGeorge syndrome; congenital heart disease (multiple); hypoparathyroidism; sensorineural hearing loss; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1) and TBX10 (T-box transcription factor 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 7E9-7E10; 1-23 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (8447691..8455069, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (8341724..8349102, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It sheds light on the events occurring downstream of Org-1 in this first step of transdifferentiation and show that alary muscle lineage-specific activation of Yorkie plays a key role in initiating the dedifferentiation and fragmentation of these muscles.
Title: Yorkie and JNK revert syncytial muscles into myoblasts during Org-1-dependent lineage reprogramming.
Reinitiation of a transcriptional program previously employed for embryonic alary muscle development, in which the factors Org-1 and Tailup are key components, leads to the development of adult Drosophila ventral longitudinal heart muscles.
Title: Org-1-dependent lineage reprogramming generates the ventral longitudinal musculature of the Drosophila heart.
An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.
Title: An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.
Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis
Title: Org-1 is required for the diversification of circular visceral muscle founder cells and normal midgut morphogenesis.
Data suggest that org-1 is a common and direct upstream regulator of slou and lb in the developmental pathway of two neighboring muscle lineages.
Title: Org-1, the Drosophila ortholog of Tbx1, is a direct activator of known identity genes during muscle specification.
Data show that a border between optomotor-blind and brinker expression domains is necessary and sufficient for inducing L5 wing vein development in the posterior regions.
Title: brinker and optomotor-blind act coordinately to initiate development of the L5 wing vein primordium in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: optomotor-blind-related-gene-1

Names: CG11202-PA; CG11202-PB; Optomotor-blind-related-1; Optomotor-blind-related-gene 1; omb-related gene-1; optomotor-blind-related gene-1; optomotor-blind-related-protein-1; org-1-PA; org-1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

8447691..8455069 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298090.1 → NP_001285019.1 optomotor-blind-related-gene-1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285019.1

Status: REVIEWED

UniProtKB/TrEMBL

O62535, Q9W3F4

Conserved Domains (1) summary

cd00182
Location:195 → 389

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
NM_078530.3 → NP_511085.2 optomotor-blind-related-gene-1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511085.2

Status: REVIEWED

UniProtKB/TrEMBL

O62535, Q9W3F4

Related

FBpp0071187

Conserved Domains (1) summary

cd00182
Location:195 → 389

TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...