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    Lip3 Lipase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lip3provided by FlyBase
    Official Full Name
    Lipase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0023495
    Locus tag
    Dmel_CG8823
    See related
    AllianceGenome:FB:FBgn0023495
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8823; dLip3; Dmel\CG8823; Dmlip3; lip3; LIP3; LIP3Dm
    Summary
    Enables phospholipase activity and triacylglycerol lipase activity. Involved in lipid catabolic process. Is expressed in embryonic/larval fat body; follicle cell; oocyte; organism; and ovary. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lip3 in Genome Data Viewer
    Location:
    87E8-87E8; 3-53 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13370240..13371904, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9195962..9197626, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene methuselah-like 12 Neighboring gene Elongator complex protein 6 Neighboring gene Dicarboxylate carrier 1 Neighboring gene Chemosensory protein A 87a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improving on nature's shortcomings: evolving a lipase for increased lipolytic activity, expression and thermostability. Alfaro-Chávez AL, et al. Protein Eng Des Sel, 2019 Sep 10. PMID 31403166
    2. Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. Voelzmann A, et al. FEBS Lett, 2016 Apr. PMID 26950647
    3. Free fatty acid determination as a tool for modeling metabolic diseases in Drosophila. Sellin J, et al. J Insect Physiol, 2020 Oct. PMID 32730782
    4. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
    5. Phylogenetic analyses and characterization of RNase X25 from Drosophila melanogaster suggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes. Ambrosio L, et al. PLoS One, 2014. PMID 25133712, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables monoacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables triacylglycerol lipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables triacylglycerol lipase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipase 3
    Names
    CG8823-PA
    Lip3-PA
    Lipase-3
    dLipase-3
    lipase3
    NP_477331.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13370240..13371904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057983.4 → NP_477331.1  lipase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477331.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46108, Q4V3U9
      UniProtKB/TrEMBL
      Q4V3V4
      Related
      FBpp0082239
      Conserved Domains (3) summary
      PLN02872
      Location:26 → 392
      PLN02872; triacylglycerol lipase
      pfam04083
      Location:30 → 89
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:315 → 355
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46108.1 O46108

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