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    Kr-h2 Kruppel homolog 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kr-h2provided by FlyBase
    Official Full Name
    Kruppel homolog 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0266449
    Locus tag
    Dmel_CG9159
    See related
    AllianceGenome:FB:FBgn0266449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-26Ba; CG9159; Dmel\CG9159; Kr-h; Kr-H2
    Summary
    Predicted to be involved in endoplasmic reticulum tubular network organization and membrane organization. Located in endomembrane system. Is expressed in adult head and adult heart. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Kr-h2 in Genome Data Viewer
    Location:
    26B4-26B4; 2-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6070990..6073961)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6070990..6073961)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Prefoldin 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43801 Neighboring gene long non-coding RNA:CR9162

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Krüppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila. Benevolenskaya EV, et al. Genet Res, 2000 Apr. PMID 10816971
    2. Chromatin topology is coupled to Polycomb group protein subnuclear organization. Wani AH, et al. Nat Commun, 2016 Jan 13. PMID 26759081, Free PMC Article
    3. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. DeSalvo MK, et al. Glia, 2011 Sep. PMID 21351158, Free PMC Article
    4. Genome-wide analysis of clustered Dorsal binding sites identifies putative target genes in the Drosophila embryo. Markstein M, et al. Proc Natl Acad Sci U S A, 2002 Jan 22. PMID 11752406, Free PMC Article
    5. Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Rathore OS, et al. Sci Rep, 2016 Feb 10. PMID 26861501, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kruppel homolog 2
    Names
    CG9159-PA
    CG9159-PB
    CG9159-PC
    Kr-h2-PA
    Kr-h2-PB
    Kr-h2-PC
    anon-26Ba
    kruppel homolog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6070990..6073961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078766.3 → NP_523490.1  kruppel homolog 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PV57, E1JHA1, Q9V447
      UniProtKB/TrEMBL
      X2J4W8
      Related
      FBpp0078823
      Conserved Domains (1) summary
      pfam03661
      Location:39 → 268
      UPF0121; uncharacterized protein family (UPF0121)

    2. NM_001298734.1 → NP_001285663.1  kruppel homolog 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PV57, E1JHA1, Q9V447
      UniProtKB/TrEMBL
      X2J4W8
      Conserved Domains (1) summary
      pfam03661
      Location:39 → 268
      UPF0121; uncharacterized protein family (UPF0121)

    3. NM_001169423.1 → NP_001162894.1  kruppel homolog 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0PV57, E1JHA1, Q9V447
      UniProtKB/TrEMBL
      X2J4W8
      Conserved Domains (1) summary
      pfam03661
      Location:39 → 268
      UPF0121; uncharacterized protein family (UPF0121)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V447.1 Q9V447
    X2J4W8 X2J4W8

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