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    mab-21 mab-21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44127, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mab-21provided by FlyBase
    Official Full Name
    mab-21provided by FlyBase
    Primary source
    FLYBASE:FBgn0029003
    Locus tag
    Dmel_CG4746
    See related
    AllianceGenome:FB:FBgn0029003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4746; Dmel\CG4746; mab-2
    Summary
    Predicted to be involved in eye development. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; dorsal epidermis primordium; ganglia; and head epidermis primordium. Used to study microphthalmia. Human ortholog(s) of this gene implicated in coloboma and syndromic microphthalmia 14. Orthologous to human MAB21L1 (mab-21 like 1) and MAB21L2 (mab-21 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mab-21 in Genome Data Viewer
    Location:
    5D2-5D2; 1-15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6008183..6013181, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5902216..5907214, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44498 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44499 Neighboring gene roughex

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Single amino acid variation in MAB21L1 is dominantly associated with congenital eye defects. Meng F, et al. J Med Genet, 2023 Jul. PMID 36446583
    2. Two cGAS-like receptors induce antiviral immunity in Drosophila. Holleufer A, et al. Nature, 2021 Sep. PMID 34261128
    3. Polycomb protein binding and looping in the ON transcriptional state. Brown JL, et al. Sci Adv, 2024 Apr 26. PMID 38657072, Free PMC Article
    4. The Hox proteins Ubx and AbdA collaborate with the transcription pausing factor M1BP to regulate gene transcription. Zouaz A, et al. EMBO J, 2017 Oct 2. PMID 28871058, Free PMC Article
    5. Chromosomal distribution of PcG proteins during Drosophila development. Nègre N, et al. PLoS Biol, 2006 Jun. PMID 16613483, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mab-21
    Names
    CG4746-PA
    mab-2
    mab-21-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6008183..6013181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143714.4 → NP_651971.2  mab-21 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651971.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3W6, Q9W447
      Related
      FBpp0070855
      Conserved Domains (1) summary
      pfam03281
      Location:68 → 350
      Mab-21; Mab-21 protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R59 Q95R59
    Q9U3W6.2 Q9U3W6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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