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    Vago vago [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32040, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vagoprovided by FlyBase
    Official Full Name
    vagoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030262
    Locus tag
    Dmel_CG2081
    See related
    AllianceGenome:FB:FBgn0030262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH70969; CG2081; DIGF-2; Dmel\CG2081; vago; VAGO
    Summary
    Involved in defense response to virus. Predicted to be located in extracellular space. Is expressed in adult fat body and adult heart. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vago in Genome Data Viewer
    Location:
    10A4-10A4; 1-33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11089290..11090219)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10983323..10984252)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sevenless Neighboring gene antisense RNA:CR44358 Neighboring gene antisense RNA:CR45604 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nora Virus VP4b and ORF1 Circulate in Hemolymph of Infected D. melanogaster with Coordinate Expression of Vago and Vir-1. Macke A, et al. Vaccines (Basel), 2020 Aug 31. PMID 32878003, Free PMC Article
    2. Dicer-2-Dependent Generation of Viral DNA from Defective Genomes of RNA Viruses Modulates Antiviral Immunity in Insects. Poirier EZ, et al. Cell Host Microbe, 2018 Mar 14. PMID 29503180, Free PMC Article
    3. Origins and diversification of animal innate immune responses against viral infections. Iwama RE, et al. Nat Ecol Evol, 2023 Feb. PMID 36635343
    4. Contact-based sequence alignment. Kleinjung J, et al. Nucleic Acids Res, 2004. PMID 15121903, Free PMC Article
    5. Innate immune pathways act synergistically to constrain RNA virus evolution in Drosophila melanogaster. Mongelli V, et al. Nat Ecol Evol, 2022 May. PMID 35273366, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vago
    Names
    CG2081-PB
    CG2081-PD
    Vago-PB
    Vago-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11089290..11090219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298177.1 → NP_001285106.1  vago, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2NUJ3, Q8MYS7, Q9VZ35
      Conserved Domains (1) summary
      pfam15430
      Location:41 → 106
      SVWC; Single domain von Willebrand factor type C

    2. NM_132452.3 → NP_572680.1  vago, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D2NUJ3, Q8MYS7, Q9VZ35
      Related
      FBpp0073283
      Conserved Domains (1) summary
      pfam15430
      Location:41 → 106
      SVWC; Single domain von Willebrand factor type C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZ35.1 Q9VZ35

    Gene LinkOut

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