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    CG42249 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32043, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42249provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259101
    Locus tag
    Dmel_CG42249
    See related
    AllianceGenome:FB:FBgn0259101
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11126; CG1961; Dmel\CG42249
    Old locus tag
    Dmel_CG11126; Dmel_CG1961
    Summary
    Enables ADP phosphatase activity and ATP hydrolysis activity. Predicted to be involved in AMP catabolic process. Predicted to be active in plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42249 in Genome Data Viewer
    Location:
    10A4-10A4; 1-33 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11096273..11108148)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10990306..11002181)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45604 Neighboring gene uncharacterized protein Neighboring gene vago Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 60A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of ecto-5'-nucleotidases and apyrases in Drosophila melanogaster. Fenckova M, et al. Insect Biochem Mol Biol, 2011 Dec. PMID 21996016
    2. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. Pillmann H, et al. BMC Bioinformatics, 2011 Jun 30. PMID 21718515, Free PMC Article
    3. [LTR retrotransposons as a source of promoters in the Drosophila genome]. Makunin IV, et al. Genetika, 2010 Sep. PMID 21061618
    4. Comparative transcriptional profiling identifies takeout as a gene that regulates life span. Bauer J, et al. Aging (Albany NY), 2010 May. PMID 20519778, Free PMC Article
    5. Characteristics of molecular-genetic organization of intercalary heterochromatin band 10A1-2 in X chromosome of Drosophila melanogaster. Babenko VN, et al. Dokl Biochem Biophys, 2009 Jan-Feb. PMID 19341102

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ADP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42249-PB
    CG42249-PC
    CG42249-PD
    NP_001259438.1
    NP_572683.1
    NP_572684.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11096273..11108148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132456.3 → NP_572684.2  uncharacterized protein Dmel_CG42249, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572684.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVD4, Q9VZ32
      Conserved Domains (3) summary
      COG0737
      Location:26 → 547
      UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
      cd07409
      Location:36 → 316
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:345 → 514
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain

    2. NM_132455.3 → NP_572683.1  uncharacterized protein Dmel_CG42249, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572683.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VZ33
      Related
      FBpp0288787
      Conserved Domains (3) summary
      TIGR01530
      Location:36 → 521
      nadN; NAD pyrophosphatase/5'-nucleotidase NadN
      cd07409
      Location:36 → 316
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:344 → 515
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain

    3. NM_001272509.1 → NP_001259438.1  uncharacterized protein Dmel_CG42249, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259438.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2RVD4, Q9VZ32
      Conserved Domains (3) summary
      COG0737
      Location:26 → 547
      UshA; 2',3'-cyclic-nucleotide 2'-phosphodiesterase/5'- or 3'-nucleotidase, 5'-nucleotidase family [Nucleotide transport and metabolism, Defense mechanisms]
      cd07409
      Location:36 → 316
      MPP_CD73_N; CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain
      pfam02872
      Location:345 → 514
      5_nucleotid_C; 5'-nucleotidase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VZ32 Q9VZ32
    Q9VZ33 Q9VZ33

    Gene LinkOut

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