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    sbm sobremesa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32397, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sbmprovided by FlyBase
    Official Full Name
    sobremesaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030574
    Locus tag
    Dmel_CG9413
    See related
    AllianceGenome:FB:FBgn0030574
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9413; Dmel\CG9413; Sbm
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport. Located in cell cortex. Is expressed in adult abdomen; adult head; and adult thorax. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sbm in Genome Data Viewer
    Location:
    12F1-12F1; 1-49 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14584733..14602580, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14478766..14496613, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene nmdyn-D6 Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene Netrin-A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Using Drosophila melanogaster to identify chemotherapy toxicity genes. King EG, et al. Genetics, 2014 Sep. PMID 25236447, Free PMC Article
    2. Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties. Reynolds B, et al. Biochem J, 2009 May 27. PMID 19335336, Free PMC Article
    3. Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. Augustin H, et al. J Neurosci, 2007 Jan 3. PMID 17202478, Free PMC Article
    4. Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth. Galagovsky D, et al. Cell Rep, 2018 Sep 18. PMID 30231999, Free PMC Article
    5. Genome-wide patterns of adaptation to temperate environments associated with transposable elements in Drosophila. González J, et al. PLoS Genet, 2010 Apr 8. PMID 20386746, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sbm modulates brain development and the timing of larval development via an amino-acid-sensitive and Dilp-independent function of glia.
      Title: Sobremesa L-type Amino Acid Transporter Expressed in Glia Is Essential for Proper Timing of Development and Brain Growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sobremesa
    Names
    CG9413-PA
    CG9413-PB
    CG9413-PC
    CG9413-PD
    sbm-PA
    sbm-PB
    sbm-PC
    sbm-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      14584733..14602580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298313.1 → NP_001285242.1  sobremesa, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285242.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5BIK9, X2JK78
      Conserved Domains (1) summary
      TIGR00911
      Location:44 → 402
      2A0308; L-type amino acid transporter

    2. NM_132738.2 → NP_572966.1  sobremesa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC3, Q9VY26
      Related
      FBpp0073760
      Conserved Domains (1) summary
      TIGR00911
      Location:44 → 523
      2A0308; L-type amino acid transporter

    3. NM_001298312.1 → NP_001285241.1  sobremesa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285241.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC3, X2JDR1
      Conserved Domains (1) summary
      TIGR00911
      Location:53 → 512
      2A0308; L-type amino acid transporter

    4. NM_167411.3 → NP_727785.1  sobremesa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPC3, Q8IR48
      Related
      FBpp0073761
      Conserved Domains (1) summary
      TIGR00911
      Location:53 → 532
      2A0308; L-type amino acid transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BIK9 Q5BIK9
    Q8IR48 Q8IR48
    Q9VY26 Q9VY26
    X2JDR1 X2JDR1
    X2JK78 X2JK78

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