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    Nepl7 Neprilysin-like 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34671, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nepl7provided by FlyBase
    Official Full Name
    Neprilysin-like 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0032442
    Locus tag
    Dmel_CG15485
    See related
    AllianceGenome:FB:FBgn0032442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15485; Dmel\CG15485
    Summary
    Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in spermatozoon. Orthologous to human KEL (Kell metallo-endopeptidase (Kell blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nepl7 in Genome Data Viewer
    Location:
    33F2-33F2; 2-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12667248..12669714, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12667248..12669714, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44596 Neighboring gene long non-coding RNA:CR44595 Neighboring gene nubbin Neighboring gene RNA and export factor binding protein 2 Neighboring gene POU domain protein 2 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 4 Neighboring gene Intraflagellar transport 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
    2. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article
    3. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. Bland ND, et al. BMC Evol Biol, 2008 Jan 23. PMID 18215274, Free PMC Article
    4. Tumour-host interactions through the lens of Drosophila. Bilder D, et al. Nat Rev Cancer, 2021 Nov. PMID 34389815, Free PMC Article
    5. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables peptidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-like 7
    Names
    CG15485-PA
    CG15485-PB
    Nepl7-PA
    Nepl7-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12667248..12669714 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135733.3 → NP_609577.2  Neprilysin-like 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609577.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEF3, Q9VK72
      Conserved Domains (2) summary
      cd08662
      Location:52 → 666
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:43 → 669
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    2. NM_001298950.1 → NP_001285879.1  Neprilysin-like 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A2VEF3, Q9VK72
      Conserved Domains (2) summary
      cd08662
      Location:52 → 666
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:43 → 669
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VK72 Q9VK72

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