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    mtgo miles to go [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtgoprovided by FlyBase
    Official Full Name
    miles to goprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259735
    Locus tag
    Dmel_CG42389
    See related
    AllianceGenome:FB:FBgn0259735
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.16; CG13260; CG13261; CG31738; CG42389; CG4668; clone 1.16; CT15043; CT15049; Dmel\CG42389
    Old locus tag
    Dmel_CG13260; Dmel_CG31738
    Summary
    Located in plasma membrane. Is expressed in adult brain; adult head; adult mushroom body; and spermatozoon. Orthologous to several human genes including FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtgo in Genome Data Viewer
    Location:
    36A4-36A9; 2-52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16545016..16663218)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16545016..16663218)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45355 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44151 Neighboring gene Transient receptor potential cation channel gamma Neighboring gene mir-2497 stem loop Neighboring gene hermaphrodite

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Miles to go (mtgo) encodes FNDC3 proteins that interact with the chaperonin subunit CCT3 and are required for NMJ branching and growth in Drosophila. Syed A, et al. Dev Biol, 2019 Jan 1. PMID 30539716, Free PMC Article
    2. Genetic Variation and Potential for Resistance Development to the tTA Overexpression Lethal System in Insects. Knudsen KE, et al. G3 (Bethesda), 2020 Apr 9. PMID 32019873, Free PMC Article
    3. Centromeric binding and activity of Protein Phosphatase 4. Lipinszki Z, et al. Nat Commun, 2015 Jan 6. PMID 25562660, Free PMC Article
    4. A genome-wide scan for genes under balancing selection in Drosophila melanogaster. Croze M, et al. BMC Evol Biol, 2017 Jan 13. PMID 28086750, Free PMC Article
    5. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Yeung K, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295802, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    miles to go
    Names
    CG42389-PE
    CG42389-PF
    CG42389-PG
    CG42389-PH
    mtgo-PE
    mtgo-PF
    mtgo-PG
    mtgo-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16545016..16663218
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144357.2 → NP_001137829.1  miles to go, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137829.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZW3
      Conserved Domains (1) summary
      cd00063
      Location:1415 → 1520
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. NM_001273575.1 → NP_001260504.1  miles to go, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260504.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD19
      Conserved Domains (1) summary
      cd00063
      Location:1130 → 1235
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. NM_135957.5 → NP_609801.3  miles to go, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609801.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJJ9
      Conserved Domains (1) summary
      cd00063
      Location:1113 → 1218
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. NM_165168.3 → NP_723981.1  miles to go, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723981.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTU0, Q9VJJ8
      Conserved Domains (1) summary
      cd00063
      Location:764 → 869
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZW3 B7YZW3
    M9PD19 M9PD19
    Q9VJJ8 Q9VJJ8
    Q9VJJ9 Q9VJJ9

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