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    Lrch Leucine-rich-repeats and calponin homology domain protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrchprovided by FlyBase
    Official Full Name
    Leucine-rich-repeats and calponin homology domain proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032633
    Locus tag
    Dmel_CG6860
    See related
    AllianceGenome:FB:FBgn0032633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6860; CT21229; dLRCH; Dmel\CG6860
    Summary
    Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Located in cell cortex and cleavage furrow. Is expressed in several structures, including anlage in statu nascendi; ganglia; head epidermis primordium; mesoderm; and tracheal primordium. Orthologous to several human genes including LRCH3 (leucine rich repeats and calponin homology domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lrch in Genome Data Viewer
    Location:
    36C7-36C7; 2-53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17367511..17384115, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17367511..17384115, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44346 Neighboring gene uncharacterized protein Neighboring gene Cytoplasmic linker protein 190 Neighboring gene RNA polymerase II subunit J

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LRCH proteins: a novel family of cytoskeletal regulators. Foussard H, et al. PLoS One, 2010 Aug 18. PMID 20805893, Free PMC Article
    2. Crosstalk between chromatin and Shavenbaby defines transcriptional output along the Drosophila intestinal stem cell lineage. Mancheno-Ferris A, et al. iScience, 2024 Jan 19. PMID 38174321, Free PMC Article
    3. Genetic Basis of Natural Variation in Spontaneous Grooming in Drosophila melanogaster. Yanagawa A, et al. G3 (Bethesda), 2020 Sep 2. PMID 32727922, Free PMC Article
    4. Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. Slack C, et al. PLoS Genet, 2010 Mar 19. PMID 20333234, Free PMC Article
    5. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich-repeats and calponin homology domain protein
    Names
    CG6860-PA
    CG6860-PB
    CG6860-PC
    Lrch-PA
    Lrch-PB
    Lrch-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17367511..17384115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165212.2 → NP_724046.1  Leucine-rich-repeats and calponin homology domain protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724046.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960C5
      Related
      FBpp0080521
      Conserved Domains (3) summary
      PRK15370
      Location:79 → 278
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      smart00033
      Location:676 → 759
      CH; Calponin homology domain
      sd00033
      Location:124 → 146
      LRR_RI; leucine-rich repeat [structural motif]

    2. NM_135990.3 → NP_609834.2  Leucine-rich-repeats and calponin homology domain protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609834.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJE6
      Related
      FBpp0080522
      Conserved Domains (4) summary
      smart00033
      Location:676 → 756
      CH; Calponin homology domain
      sd00033
      Location:124 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:124 → 161
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:124 → 179
      LRR_8; Leucine rich repeat

    3. NM_001299083.1 → NP_001286012.1  Leucine-rich-repeats and calponin homology domain protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JA56
      Conserved Domains (4) summary
      smart00033
      Location:676 → 756
      CH; Calponin homology domain
      sd00033
      Location:124 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:124 → 161
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:124 → 179
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q960C5.1 Q960C5
    Q9VJE6 Q9VJE6
    X2JA56 X2JA56

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