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    ssp3 short spindle 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ssp3provided by FlyBase
    Official Full Name
    short spindle 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032723
    Locus tag
    Dmel_CG18397
    See related
    AllianceGenome:FB:FBgn0032723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10666; CG18397; Dmel\CG18397; Ssp3
    Summary
    Located in spindle. Is expressed in adult head. Used to study Bardet-Biedl syndrome and azoospermia. Orthologous to human SCAPER (S-phase cyclin A associated protein in the ER). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ssp3 in Genome Data Viewer
    Location:
    37B5-37B6; 2-54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18916347..18943960, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18916347..18943960, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44739 Neighboring gene long non-coding RNA:CR44738 Neighboring gene long non-coding RNA:CR44740 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis. Wormser O, et al. J Med Genet, 2021 Apr. PMID 32527956, Free PMC Article
    2. GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise. Watanabe LP, et al. Sci Rep, 2021 Mar 4. PMID 33664357, Free PMC Article
    3. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
    4. Chromatin immunoprecipitation reveals a novel role for the Drosophila SoxNeuro transcription factor in axonal patterning. Girard F, et al. Dev Biol, 2006 Nov 15. PMID 16979619
    5. Male-specific fruitless isoforms target neurodevelopmental genes to specify a sexually dimorphic nervous system. Neville MC, et al. Curr Biol, 2014 Feb 3. PMID 24440396, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis.
      Title: Absence of SCAPER causes male infertility in humans and Drosophila by modulating microtubule dynamics during meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    short spindle 3
    Names
    CG18397-PA
    CG18397-PB
    ssp3-PA
    ssp3-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18916347..18943960 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299140.1 → NP_001286069.1  short spindle 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286069.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2J6U8
      Conserved Domains (4) summary
      pfam15665
      Location:868 → 1058
      FAM184; Family with sequence similarity 184, A and B
      pfam16501
      Location:111 → 206
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
      cl02488
      Location:989 → 1190
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:1109 → 1191
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_136073.3 → NP_609917.2  short spindle 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609917.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VJ35, Q9VJ36
      Related
      FBpp0080734
      Conserved Domains (4) summary
      pfam15665
      Location:870 → 1060
      FAM184; Family with sequence similarity 184, A and B
      pfam16501
      Location:113 → 208
      SCAPER_N; S phase cyclin A-associated protein in the endoplasmic reticulum
      cl02488
      Location:991 → 1192
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl20817
      Location:1111 → 1193
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJ35 Q9VJ35
    X2J6U8 X2J6U8

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