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    Jon44E Jonah 44E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jon44Eprovided by FlyBase
    Official Full Name
    Jonah 44Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001285
    Locus tag
    Dmel_CG8579
    See related
    AllianceGenome:FB:FBgn0001285
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8579; Dmel\CG8579; Jon43E; JON44E; SP100
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Jon44E in Genome Data Viewer
    Location:
    44E2-44E2; 2-59 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8691448..8692844)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4578953..4580349)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase long-chain Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pathogen Virulence Impedes Mutualist-Mediated Enhancement of Host Juvenile Growth via Inhibition of Protein Digestion. Erkosar B, et al. Cell Host Microbe, 2015 Oct 14. PMID 26439865, Free PMC Article
    2. D-Alanylation of teichoic acids contributes to Lactobacillus plantarum-mediated Drosophila growth during chronic undernutrition. Matos RC, et al. Nat Microbiol, 2017 Dec. PMID 28993620, Free PMC Article
    3. Genome-wide transcription analysis of clinal genetic variation in Drosophila. Chen Y, et al. PLoS One, 2012. PMID 22514645, Free PMC Article
    4. A postbiotic from Aspergillus oryzae attenuates the impact of heat stress in ectothermic and endothermic organisms. Kaufman JD, et al. Sci Rep, 2021 Mar 19. PMID 33742039, Free PMC Article
    5. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    jonah 44E
    Names
    CG8579-PA
    CG8579-PB
    Jon44E-PA
    Jon44E-PB
    jonah 43E
    NP_001286203.1
    NP_724699.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8691448..8692844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299274.1 → NP_001286203.1  jonah 44E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JX43
      Conserved Domains (2) summary
      smart00020
      Location:40 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:41 → 266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_165618.2 → NP_724699.1  jonah 44E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724699.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JX43
      Related
      FBpp0087783
      Conserved Domains (2) summary
      smart00020
      Location:40 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:41 → 266
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JX43 Q7JX43

    Gene LinkOut

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