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    conv convoluted [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36588, updated on 9-Dec-2024

    Summary

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    Official Symbol
    convprovided by FlyBase
    Official Full Name
    convolutedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261269
    Locus tag
    Dmel_CG8561
    See related
    AllianceGenome:FB:FBgn0261269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Als; ALS; CG8561; CT24963; dALS; Dmel\CG8561; l(2)k06507b; tartan/capricious-like
    Summary
    Involved in motor neuron axon guidance and regulation of tube length, open tracheal system. Is expressed in embryonic/larval dorsal tracheal branch; embryonic/larval neuromuscular junction; larval central nervous system; and larval somatic muscle cell. Human ortholog(s) of this gene implicated in COVID-19; X-Linked immunodeficiency 74; and primary immunodeficiency disease. Orthologous to several human genes including IGFALS (insulin like growth factor binding protein acid labile subunit); NRROS (negative regulator of reactive oxygen species); and TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See conv in Genome Data Viewer
    Location:
    50E6-50E6; 2-69 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14270729..14275495)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10158234..10163000)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Selenophosphate synthetase 1 Neighboring gene I[[h]] channel Neighboring gene tejas

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides. Arquier N, et al. Cell Metab, 2008 Apr. PMID 18396139
    2. Drosophila germ-line modulation of insulin signaling and lifespan. Flatt T, et al. Proc Natl Acad Sci U S A, 2008 Apr 29. PMID 18434551, Free PMC Article
    3. The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Behr M, et al. Dev Cell, 2003 Oct. PMID 14536062
    4. Amino acids and the humoral regulation of growth: fat bodies use slimfast. Bradley GL, et al. Cell, 2003 Sep 19. PMID 14505564
    5. Body size regulation and insulin-like growth factor signaling. Hyun S. Cell Mol Life Sci, 2013 Jul. PMID 23508807, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conv/dALS has a novel, IGF-signaling independent function in tracheal morphogenesis.
      Title: Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization.
    2. dALS antagonizes insulin-like peptide function to control animal growth as well as carbohydrate and fat metabolism.
      Title: Drosophila ALS regulates growth and metabolism through functional interaction with insulin-like peptides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube length, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    convoluted
    Names
    Acid-labile subunit
    CG8561-PA
    CG8561-PB
    acid labile substrate
    acid labile subunit
    conv-PA
    conv-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14270729..14275495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137104.3 → NP_610948.2  convoluted, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610948.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9N6
      Conserved Domains (3) summary
      cd00116
      Location:486 → 738
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:416 → 438
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:486 → 545
      LRR_8; Leucine rich repeat

    2. NM_001299487.1 → NP_001286416.1  convoluted, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9N6
      Conserved Domains (3) summary
      cd00116
      Location:486 → 738
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:416 → 438
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:486 → 545
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9N6 A1Z9N6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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