U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SA2 Stromalin 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38167, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SA2provided by FlyBase
    Official Full Name
    Stromalin 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0043865
    Locus tag
    Dmel_CG13916
    See related
    AllianceGenome:FB:FBgn0043865
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0109301.35; CG1; CG13916; Dmel\CG13916; DSA2; pf-1; SA-2; snm; SNM
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in sister chromatid cohesion. Colocalizes with condensed nuclear chromosome and nucleolus. Human ortholog(s) of this gene implicated in Holoprosencephaly 13, X-linked; Mullegama-Klein-Martinez syndrome; autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to human STAG1 (STAG1 cohesin complex component); STAG2 (STAG2 cohesin complex component); and STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SA2 in Genome Data Viewer
    Location:
    62A1-62A1; 3-0.5 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1434336..1437872, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1434336..1437872, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase 61F Neighboring gene alpha1,3-fucosyltransferase D Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44842 Neighboring gene rhomboid

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Meiotic pairing and disjunction of mini-X chromosomes in drosophila is mediated by 240-bp rDNA repeats and the homolog conjunction proteins SNM and MNM. Thomas SE, et al. Genetics, 2007 Oct. PMID 17660566, Free PMC Article
    2. Homologous pairing and the role of pairing centers in meiosis. Tsai JH, et al. J Cell Sci, 2011 Jun 15. PMID 21625006
    3. From early homologue recognition to synaptonemal complex formation. Zickler D. Chromosoma, 2006 Jun. PMID 16570189
    4. Sex Chromosome Pairing Mediated by Euchromatic Homology in Drosophila Male Meiosis. Hylton CA, et al. Genetics, 2020 Mar. PMID 31915134, Free PMC Article
    5. When size does not matter: pairing sites during meiosis. McKim KS. Cell, 2005 Dec 16. PMID 16360029

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. identification of Stromalin in Meiosis SNM) and Modifier of Mdg4 in Meiosis (MNM) required for conjunction and regular segregation in meiosis
      Title: Identification of two proteins required for conjunction and regular segregation of achiasmate homologs in Drosophila male meiosis.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    stromalin 2
    Names
    CG13916-PC
    SA2-PC
    Stromalin-2
    complementation group 1
    pairing failure-1
    stromalin in meiosis

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1434336..1437872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138265.3 → NP_612109.3  stromalin 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_612109.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q3S4X5, Q9W0F4
      Conserved Domains (1) summary
      pfam08514
      Location:134 → 217
      STAG; STAG domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3S4X5 Q3S4X5
    Q8T8V6 Q8T8V6
    Q9W0F4 Q9W0F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous