CG43367 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG43367provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0263110
Locus tag: Dmel_CG43367
See related: AllianceGenome:FB:FBgn0263110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1295; CG1308; CG1332; Dmel\CG43367
Old locus tag: Dmel_CG1295; Dmel_CG1308; Dmel_CG1332
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be active in cytosol and membrane. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and germline cell. Human ortholog(s) of this gene implicated in gray platelet syndrome. Orthologous to several human genes including NBEAL1 (neurobeachin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64A10-64A10; 3-10 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4193993..4224003)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4193993..4224003)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG43367-PC; CG43367-PD; CG43367-PE; CG43367-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4193993..4224003

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259684.1 → NP_001246613.1 uncharacterized protein Dmel_CG43367, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246613.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE09

Conserved Domains (8) summary

COG2319
Location:2228 → 2534

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1752 → 1846

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:1872 → 2151

Beach; Beige/BEACH domain

pfam15787
Location:706 → 962

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1450 → 1699

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2265 → 2303

7WD40; WD40 repeat [structural motif]

cl02567
Location:2268 → 2487

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:443 → 552

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001202119.2 → NP_001189048.2 uncharacterized protein Dmel_CG43367, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189048.2

Status: REVIEWED

UniProtKB/TrEMBL

M9MRV7

Conserved Domains (8) summary

COG2319
Location:2428 → 2734

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1952 → 2046

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:2072 → 2351

Beach; Beige/BEACH domain

pfam15787
Location:906 → 1162

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1650 → 1899

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2465 → 2503

7WD40; WD40 repeat [structural motif]

cl02567
Location:2468 → 2687

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:643 → 752

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_139612.3 → NP_647869.3 uncharacterized protein Dmel_CG43367, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647869.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9VZG5

Conserved Domains (8) summary

COG2319
Location:2386 → 2692

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1910 → 2004

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:2030 → 2309

Beach; Beige/BEACH domain

pfam15787
Location:864 → 1120

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1608 → 1857

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2423 → 2461

7WD40; WD40 repeat [structural motif]

cl02567
Location:2426 → 2645

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:601 → 710

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001259685.1 → NP_001246614.1 uncharacterized protein Dmel_CG43367, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246614.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NE09

Conserved Domains (8) summary

COG2319
Location:2228 → 2534

WD40; WD40 repeat [General function prediction only]

cd01201
Location:1752 → 1846

PH_BEACH; Pleckstrin homology domain in BEACH domain containing proteins

pfam02138
Location:1872 → 2151

Beach; Beige/BEACH domain

pfam15787
Location:706 → 962

DUF4704; Domain of unknown function (DUF4704)

pfam16057
Location:1450 → 1699

DUF4800; Domain of unknown function (DUF4800)

sd00039
Location:2265 → 2303

7WD40; WD40 repeat [structural motif]

cl02567
Location:2268 → 2487

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:443 → 552

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...