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    PGRP-SD Peptidoglycan recognition protein SD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGRP-SDprovided by FlyBase
    Official Full Name
    Peptidoglycan recognition protein SDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035806
    Locus tag
    Dmel_CG7496
    See related
    AllianceGenome:FB:FBgn0035806
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7496; Dm PGRP-SD; Dmel\CG7496; pgrp-sd
    Summary
    Enables peptidoglycan binding activity. Involved in positive regulation of peptidoglycan recognition protein signaling pathway and response to bacterium. Located in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PGRP-SD in Genome Data Viewer
    Location:
    66A8-66A8; 3-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7651180..7651900)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7644280..7645000)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin-related modifier 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ankyrin 2 Neighboring gene uncharacterized protein Neighboring gene Medium-chain acyl-CoA dehydrogenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway. Basbous N, et al. EMBO Rep, 2011 Apr. PMID 21372849, Free PMC Article
    2. Wall teichoic acids of Staphylococcus aureus limit recognition by the drosophila peptidoglycan recognition protein-SA to promote pathogenicity. Atilano ML, et al. PLoS Pathog, 2011 Dec. PMID 22144903, Free PMC Article
    3. Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity. Wang L, et al. Proc Natl Acad Sci U S A, 2008 Aug 19. PMID 18697931, Free PMC Article
    4. Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan. Leone P, et al. Mol Immunol, 2008 May. PMID 18304640
    5. A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan. Xu W, et al. Neuron, 2023 Oct 18. PMID 37582366, Free PMC Article

    See all (140) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data reveal that Drosophila PGRP-SD functions as an extracellular receptor similar to mammalian CD14
      Title: PGRP-SD, an Extracellular Pattern-Recognition Receptor, Enhances Peptidoglycan-Mediated Activation of the Drosophila Imd Pathway.
    2. interplay between the binding affinities of different PGRPs provides sufficient flexibility for the recognition of the highly diverse Gram-positive peptidoglycan
      Title: Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity.
    3. crystal structure of PGRP-SD at 1.5A resolution; findings suggest a diaminopimelic acid (DAP) specificity for PGRP-SD; hypothesis is that role of PGRP-SD is recognition of DAP-type PGNs responsible for activation of Toll pathway by Gram-negative bacteria
      Title: Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables N-acetylmuramoyl-L-alanine amidase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    enables peptidoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidoglycan binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of peptidoglycan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in peptidoglycan catabolic process IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan recognition protein SD
    Names
    CG7496-PA
    PGRP-SD-PA
    Peptidoglycan-recognition protein-SD precursor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      7651180..7651900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139888.3 → NP_648145.1  peptidoglycan recognition protein SD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648145.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q70PS3, Q70PS6, Q70PS9, Q9VS97
      UniProtKB/TrEMBL
      F3YD64
      Related
      FBpp0076519
      Conserved Domains (1) summary
      smart00701
      Location:20 → 162
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VS97.1 Q9VS97

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