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    CG11658 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39319, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11658provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036196
    Locus tag
    Dmel_CG11658
    See related
    AllianceGenome:FB:FBgn0036196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.413; dFBXO25; Dmel\CG11658; FBXO12; Fbxo25
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; somatic muscle primordium; and trunk mesoderm. Used to study attention deficit hyperactivity disorder. Orthologous to human FBXO25 (F-box protein 25) and FBXO32 (F-box protein 32). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11658 in Genome Data Viewer
    Location:
    68D2-68D2; 3-36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11699496..11708553, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11692596..11701653, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Diphthamide biosynthesis 1 Neighboring gene dynein, axonemal, intermediate chain 2 Neighboring gene Coiled-coil domain containing 56 Neighboring gene Mitochondrial Transcription Factor B1 Neighboring gene crimpled Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes. Harich B, et al. J Child Psychol Psychiatry, 2020 May. PMID 31849056, Free PMC Article
    2. The RU486-dependent activation of the GeneSwitch system in adult muscles leads to severe adverse effects in Drosophila. Zappia MP, et al. G3 (Bethesda), 2024 May 7. PMID 38409337, Free PMC Article
    3. DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm. Mendoza-Garcia P, et al. Development, 2021 Dec 1. PMID 34905617, Free PMC Article
    4. Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP. Vandehoef C, et al. Cell Rep, 2020 Jun 9. PMID 32521261, Free PMC Article
    5. Drosophila as a Model for Tumor-Induced Organ Wasting. Saavedra P, et al. Adv Exp Med Biol, 2019. PMID 31520356

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11658-PA
    CG11658-PB
    CG11658-PC
    CG11658-PD
    CG11658-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11699496..11708553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206338.2 → NP_996060.1  uncharacterized protein Dmel_CG11658, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTM4

    2. NM_140241.3 → NP_648498.1  uncharacterized protein Dmel_CG11658, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648498.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTM4
      Related
      FBpp0075855

    3. NM_206336.2 → NP_996058.1  uncharacterized protein Dmel_CG11658, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTM4

    4. NM_206337.2 → NP_996059.1  uncharacterized protein Dmel_CG11658, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996059.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTM4

    5. NM_206339.2 → NP_996061.1  uncharacterized protein Dmel_CG11658, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996061.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTM4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTM4 Q9VTM4

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