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    ND-24L NADH dehydrogenase (ubiquinone) 24 kDa subunit-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-24Lprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 24 kDa subunit-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036706
    Locus tag
    Dmel_CG6485
    See related
    AllianceGenome:FB:FBgn0036706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6485; Dmel\CG6485; dNDUFV2B; NUHM
    Summary
    Predicted to enable oxidoreductase activity. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Is expressed in adult head and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-24L in Genome Data Viewer
    Location:
    74A4-74A4; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17319969..17320811, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17313069..17313911, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45436 Neighboring gene mir-219 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. Klein P, et al. EMBO J, 2014 Feb 18. PMID 24473149, Free PMC Article
    2. Sexually Antagonistic Mitonuclear Coevolution in Duplicate Oxidative Phosphorylation Genes. Havird JC, et al. Integr Comp Biol, 2019 Oct 1. PMID 30942855
    3. Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. Walls SM Jr, et al. PLoS Genet, 2013. PMID 24339790, Free PMC Article
    4. Insights from Drosophila on mitochondrial complex I. Rhooms SK, et al. Cell Mol Life Sci, 2020 Feb. PMID 31485716, Free PMC Article
    5. Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles. Garcia CJ, et al. Cell Rep, 2017 Jul 5. PMID 28683319, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 24 kDa subunit-like
    Names
    CG6485-PA
    NADH-ubiquinone oxidoreductase 24 kDa subunit
    NADH:ubiquinone oxidoreductase 24 kDa subunit
    ND-24L-PA
    NP_648965.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17319969..17320811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140708.3 → NP_648965.1  NADH dehydrogenase (ubiquinone) 24 kDa subunit-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648965.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVF0
      Related
      FBpp0075010
      Conserved Domains (2) summary
      COG1905
      Location:34 → 193
      NuoE; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]
      pfam01257
      Location:44 → 190
      2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVF0 Q9VVF0

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