Mip Myoinhibiting peptide precursor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mipprovided by FlyBase
Official Full Name: Myoinhibiting peptide precursorprovided by FlyBase
Primary source: FLYBASE:FBgn0036713
Locus tag: Dmel_CG6456
See related: AllianceGenome:FB:FBgn0036713
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ASB; Ast-B; AST-B; AstB; AstB-1; AstB/MIP; CG6456; DAP-B; Dmel\CG6456; DmMIP1; DmMIP2; DmMIP3; DmMIP4; DmMIP5; Drm-MIP; Drm-MIP-1; Drm-MIP-2; Drm-MIP-3; Drm-MIP-4; Drm-MIP-5; mip; MIP; MIP-1; MIP-2; MIP-3; MIP-4; MIP-5; MIP1; MIP2; MIP3; MIP4; MIP5
Summary: Enables G protein-coupled receptor binding activity. Involved in negative regulation of eating behavior and neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including central nervous system; gut section; larval midgut enterocyte; myoinhibitory peptide neurons; and synaptic neuropil domain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 74A5-74A5; 3-45 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (17344947..17349666, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (17338047..17342766, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mip neuropeptides appear to promote mating receptivity both in virgins and mated females, although it is dispensable for normal mating in virgin females.
Title: Female-specific myoinhibitory peptide neurons regulate mating receptivity in Drosophila melanogaster.
MIP signaling in chemosensory neurons is an instructive signal adjusting female choice behavior to reproductive state.
Title: Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila.
MIP encodes anorexigenic brain signaling that determines body weight.MIP produces satiety responses independently of sex peptide receptor.MIP modulates behavioral responses to olfactory and gustatory cues of food.
Title: Identification of a Peptidergic Pathway Critical to Satiety Responses in Drosophila.
Our results illuminate how cell type specific versions of the Mip/dREAM complex and the general transcription machinery cooperate to drive selective gene activation during differentiation in stem cell lineages.
Title: Recruitment of Mediator Complex by Cell Type and Stage-Specific Factors Required for Tissue-Specific TAF Dependent Gene Activation in an Adult Stem Cell Lineage.
released centrally before and during night-time sleep, when the sleep drive is elevated
Title: A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide.
MIPs likely function as ancestral ligands of SPRs and could place evolutionary constraints on the MIP/SPR class.
Title: Myoinhibiting peptides are the ancestral ligands of the promiscuous Drosophila sex peptide receptor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide hormone activity	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of juvenile hormone biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: myoinhibiting peptide precursor

Names: CG6456-PA; Drostatin-B1; Drostatin-B3; Drostatin-B4; Drostatin-B5; Mip-PA; Mip-like peptide; allatostatin (B-type); allatostatin B; allatostatin B-1; allatostatin cricket-type; allatostatin-B; allatostatin-B1; allostatin B; drostatin-B2; mioinhibiting peptide precursor; myoinhibiting peptide; myoinhibitory peptide