U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG5665 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40243, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG5665provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036977
    Locus tag
    Dmel_CG5665
    See related
    AllianceGenome:FB:FBgn0036977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg5665; Dmel\CG5665
    Summary
    Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG5665 in Genome Data Viewer
    Location:
    77B5-77B6; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20358512..20359820)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20351612..20352920)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene eukaryotic translation release factor 1 Neighboring gene uncharacterized protein Neighboring gene kin17 Neighboring gene DNA primase subunit 2 Neighboring gene Toll-9

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Sirot LK, et al. Mol Biol Evol, 2014 Jun. PMID 24682282, Free PMC Article
    2. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
    3. Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Kadener S, et al. Proc Natl Acad Sci U S A, 2006 Sep 5. PMID 16938865, Free PMC Article
    4. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
    5. A large-scale resource for tissue-specific CRISPR mutagenesis in Drosophila. Port F, et al. Elife, 2020 Feb 13. PMID 32053108, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables triacylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG5665-PB
    CG5665-PC
    NP_001246844.1
    NP_649213.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20358512..20359820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259915.1 → NP_001246844.1  uncharacterized protein Dmel_CG5665, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFL7
      Conserved Domains (1) summary
      cl21494
      Location:85 → 370
      Abhydrolase; alpha/beta hydrolases

    2. NM_140956.2 → NP_649213.2  uncharacterized protein Dmel_CG5665, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649213.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VPH3
      Conserved Domains (1) summary
      cl21494
      Location:85 → 351
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NFL7 M9NFL7
    Q9VPH3 Q9VPH3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.