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    Fer1 48 related 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768661, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fer1provided by FlyBase
    Official Full Name
    48 related 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0037475
    Locus tag
    Dmel_CG33323
    See related
    AllianceGenome:FB:FBgn0037475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH30329; bHLHa30; CG10066; CG14611; CG33323; Dmel\CG33323; fer1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Is expressed in several structures, including adult antennal olfactory receptor neurons; central brain primordium; embryonic foregut; embryonic stomatogastric nervous system; and ganglia. Human ortholog(s) of this gene implicated in pancreatic agenesis 1. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Fer1 in Genome Data Viewer
    Location:
    84C5-84C6; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7136206..7141972)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2961928..2967694)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glycine-TCC 1-2 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR42738 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene GST-containing FLYWCH zinc-finger protein

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: 7140147-7141062 mobile_element_type = transposon:HB{}1242

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in developmental process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    48 related 1
    Names
    CG33323-PA
    CG33323-PB
    Fer1-PA
    Fer1-PB
    ferritin 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7136206..7141972
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275405.1NP_001262334.1  48 related 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFD8
      Conserved Domains (1) summary
      smart00353
      Location:92144
      HLH; helix loop helix domain
    2. NM_206455.3NP_996177.1  48 related 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXF5, Q9VI67
      Conserved Domains (1) summary
      cd11417
      Location:82137
      bHLH_TS_PTF1A; basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins