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    Rpt3R Regulatory particle triple-A ATPase 3-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41190, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpt3Rprovided by FlyBase
    Official Full Name
    Regulatory particle triple-A ATPase 3-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037742
    Locus tag
    Dmel_CG9475
    See related
    AllianceGenome:FB:FBgn0037742
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9475; CG9475; DmCG9475; Dmel\CG9475; Dm_Rpt3b; S6
    Summary
    Predicted to enable proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome regulatory particle, base subcomplex. Is expressed in central brain primordium; embryonic brain; fat body/gonad primordium; gonad; and organism. Orthologous to human PSMC4 (proteasome 26S subunit, ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpt3R in Genome Data Viewer
    Location:
    85E6-85E6; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9754735..9756510, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5580457..5582232, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase D3 Neighboring gene Telo2 interacting protein 1 Neighboring gene Alg12 alpha-1,6-mannosyltransferase Neighboring gene Mannose phosphate isomerase Neighboring gene Synaptosomal-associated protein 24kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of proteasomal ATPases. Wollenberg K, et al. Mol Biol Evol, 2001 Jun. PMID 11371584
    2. An AAA family tree. Fröhlich KU. J Cell Sci, 2001 May. PMID 11309190
    3. Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA). Housden BE, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29183982, Free PMC Article
    4. Analyses of nuclearly encoded mitochondrial genes suggest gene duplication as a mechanism for resolving intralocus sexually antagonistic conflict in Drosophila. Gallach M, et al. Genome Biol Evol, 2010. PMID 21037198, Free PMC Article
    5. Heterochromatin protein 1 (HP1a) positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila. Piacentini L, et al. PLoS Genet, 2009 Oct. PMID 19798443, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulatory particle triple-A ATPase 3-related
    Names
    CG9475-PC
    CG9475-PD
    Rpt3R-PC
    Rpt3R-PD
    NP_649938.2
    NP_731401.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9754735..9756510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169308.4 → NP_731401.3  regulatory particle triple-A ATPase 3-related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731401.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U157, Q9VH79
      Conserved Domains (2) summary
      PTZ00454
      Location:20 → 405
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:189 → 322
      AAA; ATPase family associated with various cellular activities (AAA)

    2. NM_141681.4 → NP_649938.2  regulatory particle triple-A ATPase 3-related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649938.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U157, Q9VH79
      Conserved Domains (2) summary
      PTZ00454
      Location:20 → 405
      PTZ00454; 26S protease regulatory subunit 6B-like protein; Provisional
      pfam00004
      Location:189 → 322
      AAA; ATPase family associated with various cellular activities (AAA)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ73 Q8MZ73
    Q9VH79 Q9VH79

    Gene LinkOut

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