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    CG11722 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11722provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037777
    Locus tag
    Dmel_CG11722
    See related
    AllianceGenome:FB:FBgn0037777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT14909; Dmel\CG11722; dNDUFAF4
    Summary
    Involved in mitochondrial respiratory chain complex I assembly. Is active in mitochondrion. Is expressed in adult head and organism. Used to study nuclear type mitochondrial complex I deficiency 15. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 15. Orthologous to human NDUFAF4 (NADH:ubiquinone oxidoreductase complex assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11722 in Genome Data Viewer
    Location:
    85F7-85F7; 3-49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10044596..10045542, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5870318..5871264, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Serpin 85F Neighboring gene uncharacterized protein Neighboring gene Molecule interacting with CasL Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial transcription factor B2 Neighboring gene uncharacterized protein Neighboring gene ohgata Neighboring gene fancl

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila MICAL regulates myofilament organization and synaptic structure. Beuchle D, et al. Mech Dev, 2007 May. PMID 17350233
    2. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article
    3. Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Yu J, et al. Development, 2016 Aug 15. PMID 27471256
    4. IDH2-mediated regulation of the biogenesis of the oxidative phosphorylation system. Murari A, et al. Sci Adv, 2022 May 13. PMID 35544578, Free PMC Article
    5. Identification of genes that promote or inhibit olfactory memory formation in Drosophila. Walkinshaw E, et al. Genetics, 2015 Apr. PMID 25644700, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11722-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10044596..10045542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141713.4 → NP_649970.1  uncharacterized protein Dmel_CG11722 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649970.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VH39
      Related
      FBpp0081683
      Conserved Domains (1) summary
      pfam06784
      Location:1 → 178
      UPF0240; uncharacterized protein family (UPF0240)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VH39.1 Q9VH39

    Gene LinkOut

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