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    Tim17a1 Tim17a1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41500, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tim17a1provided by FlyBase
    Official Full Name
    Tim17a1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038018
    Locus tag
    Dmel_CG10090
    See related
    AllianceGenome:FB:FBgn0038018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10090; Dmel\CG10090; Tim17 a1
    Summary
    Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Is expressed in adult head and spermatozoon. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tim17a1 in Genome Data Viewer
    Location:
    87B8-87B8; 3-52 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12363667..12364680, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8189389..8190402, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene MBD-R2 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 419 Neighboring gene Glutathione S transferase D10 Neighboring gene Glutathione S transferase D9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the Tim17 protein family. Žárský V, et al. Biol Direct, 2016 Oct 19. PMID 27760563, Free PMC Article
    2. Molecular population genetics of accessory gland protein genes and testis-expressed genes in Drosophila mojavensis and D. arizonae. Wagstaff BJ, et al. Genetics, 2005 Nov. PMID 16085702, Free PMC Article
    3. Heat shock protein 83 (Hsp83) facilitates methoprene-tolerant (Met) nuclear import to modulate juvenile hormone signaling. He Q, et al. J Biol Chem, 2014 Oct 3. PMID 25122763, Free PMC Article
    4. Mitochondrial-Y chromosome epistasis in Drosophila melanogaster. Ågren JA, et al. Proc Biol Sci, 2020 Oct 28. PMID 33081607, Free PMC Article
    5. Identification of genetic modifiers of TDP-43 neurotoxicity in Drosophila. Zhan L, et al. PLoS One, 2013. PMID 23468938, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tim17a1
    Names
    CG10090-PA
    CG10090-PB
    Tim17a1-PA
    Tim17a1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12363667..12364680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141923.2 → NP_650180.1  Tim17a1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650180.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ92, Q8MZE4, Q9VGA2
      UniProtKB/TrEMBL
      A0A0B4LH92
      Related
      FBpp0082080, FBtr0082610
      Conserved Domains (1) summary
      cl02381
      Location:2 → 138
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_001300372.1 → NP_001287301.1  Tim17a1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RJ92, Q8MZE4, Q9VGA2
      UniProtKB/TrEMBL
      A0A0B4LH92
      Conserved Domains (1) summary
      cl02381
      Location:2 → 138
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH92 A0A0B4LH92
    Q9VGA2.1 Q9VGA2

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