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    Act87E Actin 87E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Act87Eprovided by FlyBase
    Official Full Name
    Actin 87Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000046
    Locus tag
    Dmel_CG18290
    See related
    AllianceGenome:FB:FBgn0000046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    act 87E; ACT5; act87E; Act87e; actin; Actin; actin-87E; Actin87E; ArpC; CG18290; Dmel\CG18290; E; mus87E
    Summary
    Involved in DNA repair-dependent chromatin remodeling and ovarian fusome organization. Part of NuA4 histone acetyltransferase complex. Is expressed in several structures, including adult dorsal vessel; adult head; larval muscle cell; mesoderm; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 1 and thrombocytopenia. Orthologous to human ACTB (actin beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Act87E in Genome Data Viewer
    Location:
    87E11-87E11; 3-53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13425983..13428375)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9251705..9254097)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene yellow-e Neighboring gene Ionotropic receptor 87a Neighboring gene long non-coding RNA:CR45591 Neighboring gene yurt Neighboring gene long non-coding RNA:CR42756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diagnostic amino acids in actin genes: an idea whose time has gone. White ME, et al. Mol Biol Evol, 1999 Jun. PMID 10368964
    2. Molecular genetics of actin function. Hennessey ES, et al. Biochem J, 1993 May 1. PMID 8489492, Free PMC Article
    3. The actin genes of Drosophila: a dispersed multigene family. Fyrberg EA, et al. Cell, 1980 Feb. PMID 6244106
    4. Codon bias in actin multigene families and effects on the reconstruction of phylogenetic relationships. He M, et al. J Mol Evol, 1995 Aug. PMID 7666443
    5. Expression and function of the Drosophila ACT88F actin isoform is not restricted to the indirect flight muscles. Nongthomba U, et al. J Muscle Res Cell Motil, 2001. PMID 11519734

    See all (151) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ovarian fusome organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin 87E
    Names
    Act87E-PA
    Act87E-PB
    Act87E-PC
    CG18290-PA
    CG18290-PB
    CG18290-PC
    F-actin
    actin
    actin87E

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13425983..13428375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300385.1 → NP_001287314.1  actin 87E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
      UniProtKB/TrEMBL
      A0A0B4LH50, C6TP14
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional

    2. NM_057743.5 → NP_477091.1  actin 87E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477091.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
      UniProtKB/TrEMBL
      A0A0B4LH50, C6TP14
      Related
      FBpp0082253
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional

    3. NM_169525.2 → NP_731812.1  actin 87E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2T6, P10981, Q5U0U0, Q8MZ23, Q9VFU9
      UniProtKB/TrEMBL
      A0A0B4LH50, C6TP14
      Related
      FBpp0082254
      Conserved Domains (1) summary
      PTZ00281
      Location:1 → 376
      PTZ00281; actin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LH50 A0A0B4LH50
    P10981.1 P10981

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