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    lute lute [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    luteprovided by FlyBase
    Official Full Name
    luteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262871
    Locus tag
    Dmel_CG43226
    See related
    AllianceGenome:FB:FBgn0262871
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.289; CG14333; CG43226; CG5319; Dmel\CG43226
    Old locus tag
    Dmel_CG14333; Dmel_CG5319
    Summary
    Involved in neurogenesis. Predicted to be active in cytosol. Is expressed in larval central nervous system; larval peripheral nervous system; and organism. Orthologous to several human genes including BTBD3 (BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lute in Genome Data Viewer
    Location:
    90A3-90A5; 3-60 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17379944..17390265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13205666..13215987)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path IIa Neighboring gene long non-coding RNA:CR44256 Neighboring gene long non-coding RNA:CR43196 Neighboring gene Brf RNA polymerase III subunit Neighboring gene antisense RNA:CR44160 Neighboring gene sds22 Neighboring gene Cellular Repressor of E1A-stimulated Genes

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development. Bury FJ, et al. Dev Dyn, 2008 Nov. PMID 18855900
    2. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Gao Y, et al. Mol Cell, 2022 Apr 7. PMID 35325613
    3. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article
    4. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
    5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lute
    Names
    CG43226-PA
    CG43226-PB
    CG43226-PC
    CG43226-PD
    lute-PA
    lute-PB
    lute-PC
    lute-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17379944..17390265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260221.1 → NP_001247150.1  lute, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAF3
      Conserved Domains (4) summary
      smart00225
      Location:263 → 365
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:371 → 477
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:254 → 361
      BTB; BTB/POZ domain
      pfam08005
      Location:522 → 665
      PHR; PHR domain

    2. NM_001260220.1 → NP_001247149.1  lute, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247149.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAF3
      Conserved Domains (4) summary
      smart00225
      Location:263 → 365
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:371 → 477
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:254 → 361
      BTB; BTB/POZ domain
      pfam08005
      Location:522 → 665
      PHR; PHR domain

    3. NM_001275734.2 → NP_001262663.1  lute, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGU2
      Conserved Domains (4) summary
      smart00225
      Location:213 → 315
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:321 → 427
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:204 → 311
      BTB; BTB/POZ domain
      pfam08005
      Location:472 → 615
      PHR; PHR domain

    4. NM_142361.5 → NP_650618.1  lute, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEL0
      Related
      FBpp0082876
      Conserved Domains (4) summary
      smart00225
      Location:213 → 315
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:321 → 427
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:204 → 311
      BTB; BTB/POZ domain
      pfam08005
      Location:472 → 615
      PHR; PHR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGU2 A0A0B4KGU2
    C7LAF3 C7LAF3
    Q86M55 Q86M55
    Q9VEL0 Q9VEL0

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