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    Acsx4 Acyl-CoA synthetase X4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42355, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acsx4provided by FlyBase
    Official Full Name
    Acyl-CoA synthetase X4provided by FlyBase
    Primary source
    FLYBASE:FBgn0038734
    Locus tag
    Dmel_CG11453
    See related
    AllianceGenome:FB:FBgn0038734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11453; Dmel\CG11453
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. Is expressed in embryonic epipharynx; embryonic hindgut; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acsx4 in Genome Data Viewer
    Location:
    92B2-92B2; 3-67 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19783522..19785519)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15609244..15611241)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Acyl-CoA synthetase X2 Neighboring gene Acyl-CoA synthetase X3 Neighboring gene transfer RNA:Valine-CAC 2-6 Neighboring gene transfer RNA:Alanine-AGC 2-11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A tandem duplication in Drosophila melanogaster shows enhanced expression beyond the gene copy number. Loehlin DW, et al. Genetics, 2022 Mar 3. PMID 35100388, Free PMC Article
    2. Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Watkins PA, et al. J Lipid Res, 2007 Dec. PMID 17762044
    3. Cdk8 attenuates lipogenesis by inhibiting SREBP-dependent transcription in Drosophila. Li X, et al. Dis Model Mech, 2022 Nov 1. PMID 36305265, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Acyl-CoA synthetase X4
    Names
    Acsx4-PA
    CG11453-PA
    NP_650832.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19783522..19785519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142575.2 → NP_650832.1  Acyl-CoA synthetase X4 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P31, Q9VDU0
      Related
      FBpp0083205
      Conserved Domains (2) summary
      cd05911
      Location:46 → 519
      Firefly_Luc_like; Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL)
      COG0318
      Location:18 → 530
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P31 Q86P31
    Q9VDU0 Q9VDU0

    Gene LinkOut

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