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    CG45049 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG45049provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266409
    Locus tag
    Dmel_CG45049
    See related
    AllianceGenome:FB:FBgn0266409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17618; CG6982; Dmel\CG45049
    Old locus tag
    Dmel_CG17618; Dmel_CG6982
    Summary
    Predicted to be involved in cell-cell adhesion. Predicted to be located in septate junction. Predicted to be active in cell-cell junction. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to several human genes including TMEM47 (transmembrane protein 47). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG45049 in Genome Data Viewer
    Location:
    94C4-94C4; 3-76 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22726967..22732362)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18552689..18558084)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Iron regulatory protein 1A Neighboring gene antisense RNA:CR45648 Neighboring gene ring finger protein 220 Neighboring gene Tak1-like 2 Neighboring gene Dicer-1 Neighboring gene uncharacterized protein Neighboring gene vreteno

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation transfer between genomes: protein-protein interologs and protein-DNA regulogs. Yu H, et al. Genome Res, 2004 Jun. PMID 15173116, Free PMC Article
    2. Claudin complexities at the apical junctional complex. Tepass U. Nat Cell Biol, 2003 Jul. PMID 12833061
    3. The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Nelson KS, et al. Genetics, 2010 Jul. PMID 20407131, Free PMC Article
    4. Organization and function of the blood-brain barrier in Drosophila. Stork T, et al. J Neurosci, 2008 Jan 16. PMID 18199760, Free PMC Article
    5. Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control. Wu VM, et al. J Cell Biol, 2004 Jan 19. PMID 14734539, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in establishment of glial blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in septate junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG45049-PB
    CG45049-PC
    CG45049-PD
    CG45049-PE
    CG45049-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22726967..22732362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104407.3 → NP_001097877.1  uncharacterized protein Dmel_CG45049, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097877.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCV1
      Conserved Domains (1) summary
      cl21598
      Location:80 → 179
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. NM_001300543.1 → NP_001287472.1  uncharacterized protein Dmel_CG45049, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHK8
      Conserved Domains (1) summary
      cl21598
      Location:150 → 249
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. NM_001104406.3 → NP_001097876.1  uncharacterized protein Dmel_CG45049, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCV1
      Conserved Domains (1) summary
      cl21598
      Location:80 → 179
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    4. NM_001300542.1 → NP_001287471.1  uncharacterized protein Dmel_CG45049, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHK8
      Conserved Domains (1) summary
      cl21598
      Location:150 → 249
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    5. NM_001300544.1 → NP_001287473.1  uncharacterized protein Dmel_CG45049, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287473.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCV1
      Conserved Domains (1) summary
      cl21598
      Location:80 → 179
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHK8 A0A0B4LHK8
    Q9VCV1 Q9VCV1

    Gene LinkOut

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