U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Lgr3 Leucine-rich repeat-containing G protein-coupled receptor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43098, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Lgr3provided by FlyBase
    Official Full Name
    Leucine-rich repeat-containing G protein-coupled receptor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0039354
    Locus tag
    Dmel_CG31096
    See related
    AllianceGenome:FB:FBgn0039354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.25; anon-WO0170980.26; CG31096; CG5042; CG5046; CT16193; dLGR3; DLGR3; Dmel\CG31096; lgr3; LGR3
    Summary
    Enables G protein-coupled receptor activity and insulin-like growth factor binding activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of developmental growth; and negative regulation of pupariation. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including fat body; ganglia; gland; gonad; and gut section. Human ortholog(s) of this gene implicated in cryptorchidism. Orthologous to human RXFP1 (relaxin family peptide receptor 1) and RXFP2 (relaxin family peptide receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Lgr3 in Genome Data Viewer
    Location:
    96E8-96E9; 3-88 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25665809..25677214)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21491531..21502936)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tankyrase Neighboring gene antisense RNA:CR46101 Neighboring gene antisense RNA:CR45208 Neighboring gene Ras association domain family member 8 Neighboring gene long non-coding RNA:CR45225 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma Neighboring gene Ribosomal protein L27

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sex-specific regulation of Lgr3 in Drosophila neurons. Meissner GW, et al. Proc Natl Acad Sci U S A, 2016 Mar 1. PMID 26884206, Free PMC Article
    2. Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster. Van Hiel MB, et al. Peptides, 2015 Jun. PMID 25064813
    3. Glia-specific expression of neuropeptide receptor Lgr4 regulates development and adult physiology in Drosophila. Miao H, et al. J Neurosci Res, 2024 Jan. PMID 38284837
    4. Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability. Colombani J, et al. Curr Biol, 2015 Oct 19. PMID 26441350
    5. Dilp8 and its candidate receptor, Drl, are involved in the transdetermination of the Drosophila imaginal disc. Nemoto K, et al. Genes Cells, 2023 Dec. PMID 37817293

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
      Title: Ecdysone regulates the Drosophila imaginal disc epithelial barrier, determining the length of regeneration checkpoint delay.
    2. The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
      Title: The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and morphogenetic subprograms via epidermis-to-neuron Dilp8-Lgr3 signal induction.
    3. Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
      Title: Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain.
    4. Here we demonstrate that the Drosophila relaxin receptor homolog Lgr3, a leucine-rich repeat-containing G-protein-coupled receptor, is required for Dilp8-dependent growth coordination and developmental delay during the regeneration checkpoint; we demonstrate that Lgr3 activity in both the CNS and PG is necessary for NOS activation in the PG following damage
      Title: Growth Coordination During Drosophila melanogaster Imaginal Disc Regeneration Is Mediated by Signaling Through the Relaxin Receptor Lgr3 in the Prothoracic Gland.
    5. Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3) mediates the checkpoint function of Dilp8 for entry into maturation. Two Lgr3-positive neurons in each brain lobe are required to induce a developmental delay upon overexpression of Dilp8.
      Title: Drosophila Lgr3 Couples Organ Growth with Maturation and Ensures Developmental Stability.
    6. Coordinated regulation of Lgr3 by Fru and Dsx marks a point of convergence of the two branches of the sex-determination hierarchy
      Title: Sex-specific regulation of Lgr3 in Drosophila neurons.
    7. Mutation of Lgr3 suppresses the delay in pupariation induced by imaginal disc growth perturbation or ectopic Dilp8 expression.
      Title: Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing.
    8. dLGR3 is expressed in the female fat body, while the expression of dLGR4 peaks in the midgut of both the wandering and adult stage.
      Title: Cloning, constitutive activity and expression profiling of two receptors related to relaxin receptors in Drosophila melanogaster.
    9. this study shows Lgr3 is a Dilp8 receptor
      Title: A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables neuropeptide receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of developmental growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Leucine-rich repeat-containing G protein-coupled receptor 3
    Names
    CG31096-PA
    Lgr3-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25665809..25677214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170236.2 → NP_733115.1  Leucine-rich repeat-containing G protein-coupled receptor 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733115.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86P34, Q9VBP0
      Related
      FBpp0084273
      Conserved Domains (5) summary
      cd00112
      Location:32 → 65
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00116
      Location:196 → 354
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:181 → 204
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00001
      Location:447 → 704
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      pfam13855
      Location:179 → 239
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P34 Q86P34
    Q9VBP0 Q9VBP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous