U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Jon99Fii Jonah 99Fii [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43621, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Jon99Fiiprovided by FlyBase
    Official Full Name
    Jonah 99Fiiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039777
    Locus tag
    Dmel_CG2229
    See related
    AllianceGenome:FB:FBgn0039777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2229; Dmel\CG2229; Jon99F; Jon99fii; Jon99FII; SP135
    Summary
    Enables serine hydrolase activity. Predicted to be involved in innate immune response and proteolysis. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Jon99Fii in Genome Data Viewer
    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30487016..30487928, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26312738..26313650, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ceramidase Neighboring gene prolyl-4-hydroxylase-alpha EFB Neighboring gene sanpodo Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha MP

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Hang S, et al. Cell Host Microbe, 2014 Nov 12. PMID 25525791, Free PMC Article
    2. Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Meers MP, et al. Elife, 2017 Mar 27. PMID 28346137, Free PMC Article
    3. Prolyl 4-hydroxylase alpha-related proteins in Drosophila melanogaster: tissue-specific embryonic expression of the 99F8-9 cluster. Abrams EW, et al. Mech Dev, 2002 Mar. PMID 11850189
    4. Isolation of regulators of Drosophila immune defense genes by a double interaction screen in yeast. Junell A, et al. Insect Biochem Mol Biol, 2007 Mar. PMID 17296495
    5. The Jonah genes: a new multigene family in Drosophila melanogaster. Carlson JR, et al. Dev Biol, 1985 Apr. PMID 2416610

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    jonah 99Fii
    Names
    CG2229-PA
    Jon99Fii-PA
    jonah 99F
    NP_651799.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30487016..30487928 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143542.2 → NP_651799.1  jonah 99Fii [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651799.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK8, Q9VA67
      Related
      FBpp0085052
      Conserved Domains (2) summary
      smart00020
      Location:37 → 259
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:38 → 262
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VA67 Q9VA67

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools